Recombinant human CXCL16 protein (His tag)
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Recombinant human CXCL16 protein (His tag) is a Human Fragment protein, in the 1 to 224 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
SCYB16, SRPSOX, UNQ2759/PRO6714, CXCL16, C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, SR-PSOX
- FuncS
Supplier Data
Functional Studies - Recombinant human CXCL16 protein (His tag) (AB276323)
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with mouse CXCR6.
The ED50 for this effect is 50-250 ng/mL.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human CXCL16 protein (His tag) (AB276323)
SDS-PAGE analysis of ab276323
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CXCL16 plays a critical role in the immune response by mediating leukocyte migration. It acts as a chemoattractant for T cells especially those expressing the CXCR6 receptor facilitating their movement to sites of inflammation or injury. CXCL16 is not known to be part of a larger protein complex but interacts independently to moderate immune functions. It also participates in scavenging oxidized low-density lipoproteins linking it to processes in atherogenesis.
Pathways
CXCL16 is an important player in the inflammatory and immune pathways. It is involved in the NF-kB signaling pathway which regulates inflammatory responses and the chemokine signaling pathway. Through these pathways CXCL16 closely interacts with other chemokines and cytokines such as CCR5 and IL-8 helping coordinate immune surveillance and inflammatory cascade.
Specifications
Form
Lyophilized
General info
Function
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Sequence similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Post-translational modifications
Glycosylated.
Target data
Complementary Products
Product promise
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