Recombinant Human CXCL2 Protein (Active)
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- What is this?
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Recombinant Human CXCL2 Protein (Active) is a Human Full Length protein, in the 35 to 107 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, Mass Spec, HPLC, FuncS.
View Alternative Names
GRO2, GROB, MIP2A, SCYB2, CXCL2, C-X-C motif chemokine 2, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, Gro-beta, MIP2-alpha
- Biological Activity
Lab
Biological Activity - Recombinant Human CXCL2 Protein (Active) (AB307353)
Fully biologically active determined by dose dependent induction of cell migration/chemotaxis of BaF3 mouse pro-B cells overexpressing human CXCR2.
ED50 is ≤ 160 ng/ml, corresponding to a specific activity of 6.25 x 103 units/mg.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human CXCL2 Protein (Active) (AB307353)
Predicted MW is 7949.47 Da (+/- 10 Da by ESI-TOF). Observed MW is 7950.01 Da.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human CXCL2 Protein (Active) (AB307353)
SDS-PAGE analysis of ab307353
- HPLC
Supplier Data
HPLC - Recombinant Human CXCL2 Protein (Active) (AB307353)
HPLC analysis of ab307353
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CXCL2 attracts and activates neutrophils as part of the innate immune response. It acts independently not as part of a larger complex to provoke a chemotactic response guiding neutrophils to areas of tissue injury. CXCL2 also promotes the release of other cytokines and enzymes that contribute to inflammation. Its activity is mediated through its interaction with receptors like CXCR2 on target cell surfaces.
Pathways
CXCL2 is involved in inflammatory signaling and leukocyte migration. It holds importance in the chemokine signaling pathway which regulates leukocyte trafficking. CXCL2 interacts with proteins like CXCR2 influencing the inflammation process by activating downstream kinases and other signal transduction molecules such as mitogen-activated protein kinases (MAPKs).
Specifications
Form
Lyophilized
Additional notes
SDS-PAGE >= 95%
General info
Function
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
Sequence similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Post-translational modifications
The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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