Recombinant Human CXCL4L1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CXCL4L1 also known as platelet factor 4 variant 1 or PF-4alt is a chemokine with a molecular weight of approximately 7.8 kDa. CXCL4L1 is expressed mainly in platelets and can be released upon platelet activation. It shares significant homology with other members of the CXC chemokine family particularly CXCL4. Importantly its location in secretory granules of platelets indicates it plays a role in the immune response and inflammation.

Biological function summary

CXCL4L1 mediates interactions between immune cells and the vascular endothelium. It is not part of a larger protein complex. CXCL4L1 attracts monocytes and T-cells influencing their migration and adhesion. Its angiostatic properties help regulate angiogenesis the process of new blood vessel formation. Researchers observe its involvement in wound healing and tissue repair providing important regulation of cellular environments.

Pathways

CXCL4L1 engages in the signaling mechanisms that involve chemokine and integrin interactions. These include the CXCR3 receptor pathway which it shares with similar proteins like CXCL9 and CXCL10. The protein's ability to inhibit angiogenesis connects it to pathways related to the vascular endothelial growth factor (VEGF) influencing endothelial cell proliferation and vessel permeability. Its interaction with these pathways underlies its regulatory capacities in vascular biology and immune modulation.

CXCL4L1 exhibits relevant connections to cancer and cardiovascular diseases. Its angiostatic and immune-regulating properties impact tumor growth making it a potential target in cancer research. In cardiovascular disorders studies suggest CXCL4L1 might influence atherosclerosis development. The protein forms part of a complex disease network often interacting with other chemokines and molecules like CXCL12 affecting cell behavior and contributing to disease progression.