Recombinant Human CXL16 Protein is a Human Fragment protein, in the 30 to 205 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, SDS-PAGE, MS.
>=95% HPLC
<= 0.005 EU/µg
HEK 293 cells
Tag free
HPLC, SDS-PAGE, MS
No
N E G S V T G S C Y C G K R I S S D S P P S V Q F M N R L R K H L R A Y H R C L Y Y T R F Q L L S W S V C G G N K D P W V Q E L M S C L D L K E C G H A Y S G I V A H Q K H L L P T S P P I S Q A S E G A S S D I H T P A Q M L L S T L Q S T Q R P T L P V G S L S S D K E L T R P N E T T I H T A G H S L A A G P E A G E N Q K Q P E K N A G P T A R T S A T
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
SCYB16, SRPSOX, UNQ2759/PRO6714, SCYB16, CXCL16, UNQ2759/PRO6714, SRPSOX, C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, SR-PSOX
Recombinant Human CXL16 Protein is a Human Fragment protein, in the 30 to 205 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, SDS-PAGE, MS.
>=95% HPLC
<= 0.005 EU/µg
HEK 293 cells
Tag free
HPLC, SDS-PAGE, MS
No
Yes
Human
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
N E G S V T G S C Y C G K R I S S D S P P S V Q F M N R L R K H L R A Y H R C L Y Y T R F Q L L S W S V C G G N K D P W V Q E L M S C L D L K E C G H A Y S G I V A H Q K H L L P T S P P I S Q A S E G A S S D I H T P A Q M L L S T L Q S T Q R P T L P V G S L S S D K E L T R P N E T T I H T A G H S L A A G P E A G E N Q K Q P E K N A G P T A R T S A T
Fragment
19.1 kDa
19.1 kDa
30 to 205
Recombinant
Lyophilized
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Belongs to the intercrine alpha (chemokine CxC) family.
Glycosylated.
Blue Ice
Ambient
Ambient
This supplementary information is collated from multiple sources and compiled automatically.
CXCL16 also known as SR-PSOX is a chemokine that functions primarily in cellular signaling. It weighs approximately 32 kDa and exists in both membrane-bound and soluble forms. Primarily found in the spleen liver lungs and kidneys CXCL16 gets highly expressed on the surface of antigen-presenting cells such as dendritic cells and macrophages. This expression enables CXCL16 to perform its role in cell migration and adhesion by binding to its receptor CXCR6.
CXCL16 plays a critical role in the immune response by mediating leukocyte migration. It acts as a chemoattractant for T cells especially those expressing the CXCR6 receptor facilitating their movement to sites of inflammation or injury. CXCL16 is not known to be part of a larger protein complex but interacts independently to moderate immune functions. It also participates in scavenging oxidized low-density lipoproteins linking it to processes in atherogenesis.
CXCL16 is an important player in the inflammatory and immune pathways. It is involved in the NF-kB signaling pathway which regulates inflammatory responses and the chemokine signaling pathway. Through these pathways CXCL16 closely interacts with other chemokines and cytokines such as CCR5 and IL-8 helping coordinate immune surveillance and inflammatory cascade.
CXCL16 is heavily implicated in atherosclerosis and rheumatoid arthritis. In atherosclerosis CXCL16 contributes to the accumulation of macrophages and foam cell formation in plaques. This connection associates it with inflammatory molecules like TNF-alpha. In rheumatoid arthritis CXCL16 expression is increased in synovial tissues contributing to tissue damage and inflammation potentially linked through interactions with other inflammatory mediators such as IL-6.
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SDS-page analysis of ab313366
Mass determination by ESI-TOF. Predicted MW is 19145.66 (+/- 10Da by ESI-TOF). Observed MW is 19145.87
HPLC analysis of ab313366
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