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Recombinant Human CXL16 Protein is a Human Fragment protein, in the 30 to 205 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, SDS-PAGE, MS.

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Images

SDS-PAGE - Recombinant Human CXL16 Protein (AB313366), expandable thumbnail
  • Mass Spectrometry - Recombinant Human CXL16 Protein (AB313366), expandable thumbnail
  • HPLC - Recombinant Human CXL16 Protein (AB313366), expandable thumbnail

Key facts

Purity

>=95% HPLC

Endotoxin level

<= 0.005 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

HPLC, SDS-PAGE, MS

Biologically active

No

Amino acid sequence

N E G S V T G S C Y C G K R I S S D S P P S V Q F M N R L R K H L R A Y H R C L Y Y T R F Q L L S W S V C G G N K D P W V Q E L M S C L D L K E C G H A Y S G I V A H Q K H L L P T S P P I S Q A S E G A S S D I H T P A Q M L L S T L Q S T Q R P T L P V G S L S S D K E L T R P N E T T I H T A G H S L A A G P E A G E N Q K Q P E K N A G P T A R T S A T

Reactivity data

Application

HPLC

Reactivity

Reacts

Dilution info

-

Notes

-

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

MS

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Alternative names

Recommended products

Recombinant Human CXL16 Protein is a Human Fragment protein, in the 30 to 205 aa range, expressed in HEK 293, with >=95% purity, <= 0.005 EU/µg endotoxin level and suitable for HPLC, SDS-PAGE, MS.

Key facts

Purity

>=95% HPLC

Endotoxin level

<= 0.005 EU/µg

Expression system

HEK 293 cells

Applications

HPLC, SDS-PAGE, MS

Accession
Q9H2A7-1
Animal free

Yes

Species

Human

Concentration
Loading...
Storage buffer

pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

Sequence info

Amino acid sequence

N E G S V T G S C Y C G K R I S S D S P P S V Q F M N R L R K H L R A Y H R C L Y Y T R F Q L L S W S V C G G N K D P W V Q E L M S C L D L K E C G H A Y S G I V A H Q K H L L P T S P P I S Q A S E G A S S D I H T P A Q M L L S T L Q S T Q R P T L P V G S L S S D K E L T R P N E T T I H T A G H S L A A G P E A G E N Q K Q P E K N A G P T A R T S A T

Accession

Q9H2A7

Protein length

Fragment

Predicted molecular weight

19.1 kDa

Amino acids

30 to 205

Nature

Recombinant

Specifications

Form

Lyophilized

General info

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Post-translational modifications

Glycosylated.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CXCL16 also known as SR-PSOX is a chemokine that functions primarily in cellular signaling. It weighs approximately 32 kDa and exists in both membrane-bound and soluble forms. Primarily found in the spleen liver lungs and kidneys CXCL16 gets highly expressed on the surface of antigen-presenting cells such as dendritic cells and macrophages. This expression enables CXCL16 to perform its role in cell migration and adhesion by binding to its receptor CXCR6.

Biological function summary

CXCL16 plays a critical role in the immune response by mediating leukocyte migration. It acts as a chemoattractant for T cells especially those expressing the CXCR6 receptor facilitating their movement to sites of inflammation or injury. CXCL16 is not known to be part of a larger protein complex but interacts independently to moderate immune functions. It also participates in scavenging oxidized low-density lipoproteins linking it to processes in atherogenesis.

Pathways

CXCL16 is an important player in the inflammatory and immune pathways. It is involved in the NF-kB signaling pathway which regulates inflammatory responses and the chemokine signaling pathway. Through these pathways CXCL16 closely interacts with other chemokines and cytokines such as CCR5 and IL-8 helping coordinate immune surveillance and inflammatory cascade.

Associated diseases and disorders

CXCL16 is heavily implicated in atherosclerosis and rheumatoid arthritis. In atherosclerosis CXCL16 contributes to the accumulation of macrophages and foam cell formation in plaques. This connection associates it with inflammatory molecules like TNF-alpha. In rheumatoid arthritis CXCL16 expression is increased in synovial tissues contributing to tissue damage and inflammation potentially linked through interactions with other inflammatory mediators such as IL-6.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

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3 product images

  • SDS-PAGE - Recombinant Human CXL16 Protein (ab313366), expandable thumbnail

    SDS-PAGE - Recombinant Human CXL16 Protein (ab313366)

    SDS-page analysis of ab313366

  • Mass Spectrometry - Recombinant Human CXL16 Protein (ab313366), expandable thumbnail

    Mass Spectrometry - Recombinant Human CXL16 Protein (ab313366)

    Mass determination by ESI-TOF. Predicted MW is 19145.66 (+/- 10Da by ESI-TOF). Observed MW is 19145.87

  • HPLC - Recombinant Human CXL16 Protein (ab313366), expandable thumbnail

    HPLC - Recombinant Human CXL16 Protein (ab313366)

    HPLC analysis of ab313366

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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