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AB126696

Recombinant Human Cyclin A2 protein (His tag N-Terminus)

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(1 Publication)

Recombinant Human Cyclin A2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 432 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

CCN1, CCNA, CCNA2, Cyclin-A2, Cyclin-A, Cyclin A

1 Images
SDS-PAGE - Recombinant Human Cyclin A2 protein (His tag N-Terminus) (AB126696)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Cyclin A2 protein (His tag N-Terminus) (AB126696)

15% SDS-PAGE analysis of 3 µg of ab126696 (Cyclin A protein).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P20248

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIVLEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL","proteinLength":"Full Length","predictedMolecularWeight":"51.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":432,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P20248","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab126696 is purified by conventional chromatography techniques.

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General info

Function

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Post-translational modifications

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
See full target information CCNA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 84:1224-1242.e13 PubMed38458201

2024

CDK-independent role of D-type cyclins in regulating DNA mismatch repair.

Applications

Unspecified application

Species

Unspecified reactive species

Gergely Rona,Bearach Miwatani-Minter,Qingyue Zhang,Hailey V Goldberg,Marc A Kerzhnerman,Jesse B Howard,Daniele Simoneschi,Ethan Lane,John W Hobbs,Elizabeth Sassani,Andrew A Wang,Sarah Keegan,Daniel J Laverty,Cortt G Piett,Lorinc S Pongor,Miranda Li Xu,Joshua Andrade,Anish Thomas,Piotr Sicinski,Manor Askenazi,Beatrix Ueberheide,David Fenyö,Zachary D Nagel,Michele Pagano
View all publications
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Complementary Products

Primary Antibodies

AB181591

Anti-Cyclin A2 antibody [EPR17351]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin A2 antibody [EPR17351] (AB181591)

  • 5
  • 3
Proteins & Peptides

AB111646

Recombinant Human CDK2 protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human CDK2 protein (His tag C-Terminus) (AB111646)

  • 0
  • 0
Proteins & Peptides

AB128445

Recombinant Human Cyclin B1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Cyclin B1 protein (His tag N-Terminus) (AB128445)

  • 0
  • 0
Primary Antibodies

AB32053

Anti-Cyclin B1 antibody [Y106]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin B1 antibody [Y106] (AB32053)

  • 5
  • 4

Product promise

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