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AB127682

Recombinant Human Cyclin C protein

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Recombinant Human Cyclin C protein is a Human Full Length protein, in the 1 to 283 aa range, expressed in Baculovirus infected Sf9 cells, with >70%, suitable for SDS-PAGE, WB.

View Alternative Names

Cyclin-C, SRB11 homolog, hSRB11, CCNC

1 Images
SDS-PAGE - Recombinant Human Cyclin C protein (AB127682)
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Supplier Data

SDS-PAGE - Recombinant Human Cyclin C protein (AB127682)

SDS-PAGE analysis of ab127682.

Key facts

Purity

>70% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE

applications

Biologically active

No

Accession

P24863

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Complementary Products

Primary Antibodies

AB85927

Anti-Cyclin C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cyclin C antibody (AB85927)

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Proteins & Peptides

AB126696

Recombinant Human Cyclin A2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Cyclin A2 protein (His tag N-Terminus) (AB126696)

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Proteins & Peptides

AB131703

Recombinant Human KIST/KIS protein

SDS-PAGE - Recombinant Human KIST/KIS protein (AB131703)

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Proteins & Peptides

AB96771

Recombinant Human UGDH protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human UGDH protein (His tag N-Terminus) (AB96771)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"55 kDa","actualMolecularWeight":null,"aminoAcidEnd":283,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P24863","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Sequence similarities

Belongs to the cyclin family. Cyclin C subfamily.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
See full target information CCNC
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Product promise

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