Recombinant Human Cyclin E1 protein is a Human Full Length protein, in the 1 to 410 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for SDS-PAGE, WB.
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- Science advances 9:eadi38212023LncRNA EILA promotes CDK4/6 inhibitor resistance in breast cancer by stabilizing cyclin E1 protein.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZijie Cai,Qianfeng Shi,Yudong Li,Liang Jin,Shunying Li,Lok Lam Wong,Jingru Wang,Xiaoting Jiang,Mengdi Zhu,Jinna Lin,Qi Wang,Wang Yang,Yujie Liu,Jun Zhang,Chang Gong,Herui Yao,Yandan Yao,Qiang LiuPubMed 37801505
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- Tag free
- Applications
- SDS-PAGE, WB
- Biologically active
- No
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Essential for the control of the cell cycle at the G1/S (start) transition.
Alternative names
CCNE, CCNE1, G1/S-specific cyclin-E1
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Recombinant Human Cyclin E1 protein is a Human Full Length protein, in the 1 to 410 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for SDS-PAGE, WB.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- Tag free
- Applications
- SDS-PAGE, WB
- Biologically active
- No
- Accession
- P24864-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.003% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Sequence info
Amino acid sequence
- Accession
- P24864
- Protein length
- Full Length
- Predicted molecular weight
- 73 kDa
- Amino acids
- 1 to 410
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
Purity tested by densitometry. Affinity purified.
General info
- Function
Essential for the control of the cell cycle at the G1/S (start) transition.
- Sequence similarities
Belongs to the cyclin family. Cyclin E subfamily.
- Post-translational modifications
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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1 product image
SDS-PAGE - Recombinant Human Cyclin E1 protein (ab119719)
SDS Page analysis of ab119719
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Product protocols
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