Recombinant Human Cyclin H/p34 protein is a Human Full Length protein, in the 1 to 323 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for WB.
Images
Key facts
- Purity
- >90% Densitometry
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- His tag N-Terminus
- Applications
- WB
- Biologically active
- No
Amino acid sequence
M Y H N S S Q K R H W T F S S E E Q L A R L R A D A N R K F R C K A V A N G K V L P N D P V F L E P H E E M T L C K Y Y E K R L L E F C S V F K P A M P R S V V G T A C M Y F K R F Y L N N S V M E Y H P R I I M L T C A F L A C K V D E F N V S S P Q F V G N L R E S P L G Q E K A L E Q I L E Y E L L L I Q Q L N F H L I V H N P Y R P F E G F L I D L K T R Y P I L E N P E I L R K T A D D F L N R I A L T D A Y L L Y T P S Q I A L T A I L S S A S R A G I T M E S Y L S E S L M L K E N R T C L S Q L L D I M K S M R N L V K K Y E P P R S E E V A V L K Q K L E R C H S A E L A L N V I T K K R K G Y E D D D Y V S K K S K H E E E E W T D D D L V E S L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Alternative names
Cyclin-H, MO15-associated protein, p34, p37, CCNH
Recommended products
Recombinant Human Cyclin H/p34 protein is a Human Full Length protein, in the 1 to 323 aa range, expressed in Baculovirus infected Sf9, with >90% purity and suitable for WB.
Key facts
- Purity
- >90% Densitometry
- Expression system
- Baculovirus infected Sf9 cells
- Tags
- His tag N-Terminus
- Applications
- WB
- Biologically active
- No
- Accession
- P51946-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7
Preservative: 0.01% Imidazole
Constituents: 25% Glycerol (glycerin, glycerine), 1.75% Sodium chloride, 0.71% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF
Sequence info
Amino acid sequence
- M Y H N S S Q K R H W T F S S E E Q L A R L R A D A N R K F R C K A V A N G K V L P N D P V F L E P H E E M T L C K Y Y E K R L L E F C S V F K P A M P R S V V G T A C M Y F K R F Y L N N S V M E Y H P R I I M L T C A F L A C K V D E F N V S S P Q F V G N L R E S P L G Q E K A L E Q I L E Y E L L L I Q Q L N F H L I V H N P Y R P F E G F L I D L K T R Y P I L E N P E I L R K T A D D F L N R I A L T D A Y L L Y T P S Q I A L T A I L S S A S R A G I T M E S Y L S E S L M L K E N R T C L S Q L L D I M K S M R N L V K K Y E P P R S E E V A V L K Q K L E R C H S A E L A L N V I T K K R K G Y E D D D Y V S K K S K H E E E E W T D D D L V E S L
- Accession
- P51946
- Protein length
- Full Length
- Predicted molecular weight
- 39 kDa
- Amino acids
- 1 to 323
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
Affinity purified.
General info
- Function
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
- Sequence similarities
Belongs to the cyclin family. Cyclin C subfamily.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as Cyclin H
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human Cyclin H/p34 protein (ab174062)
SDS-PAGE showing ab174062
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com