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AB126694

Recombinant Human Cyt 19 protein

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Recombinant Human Cyt 19 protein is a Human Full Length protein, in the 1 to 375 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CYT19, AS3MT, Arsenite methyltransferase, Methylarsonite methyltransferase, S-adenosyl-L-methionine:arsenic(III) methyltransferase

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SDS-PAGE - Recombinant Human Cyt 19 protein (AB126694)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Cyt 19 protein (AB126694)

15% SDS-PAGE analysis of 3 μg of ab126694 (Cyt 19 protein).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9HBK9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLENCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLGEAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGALYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGITGHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLAEESDSMKSRCVPDAAGGCCGTKKSC","proteinLength":"Full Length","predictedMolecularWeight":"44.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":375,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HBK9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cyt 19 also known as CYP19 or aromatase is an important enzyme involved in steroid biosynthesis. It weighs about 58 kDa and is expressed in various tissues including adipose tissue gonads and the brain. The enzyme facilitates the conversion of androgens to estrogens by adding an aromatic ring a reaction necessary for maintaining hormone balance. This enzyme is integral to processes involving sex steroid formation and regulation.
Biological function summary

Cyt 19 plays a role in sexual development and reproductive function. It is a part of the cytochrome P450 enzyme family which is a group of heme-thiolate monooxygenases. As part of the family Cyt 19 contributes to the synthesis of estrogens from testosterone and has implications for fertility and gonadal function. Estrogens synthesized by Cyt 19 influence secondary sexual traits and regulate reproductive systems across various species.

Pathways

Cyt 19 influences the steroid biosynthesis and estrogen signaling pathways. It works closely with proteins like steroidogenic acute regulatory protein (StAR) and cytochrome P450 reductase which assist in electron transport necessary for its enzymatic activity. These pathways ensure the availability of estrogens important for modulating various physiological processes including reproductive organ function and bone density regulation.

Cyt 19 shows significant relevance in the context of breast cancer and polycystic ovary syndrome (PCOS). Anomalous expression or activity of Cyt 19 influences estrogen levels which can drive the proliferation of estrogen-receptor-positive breast cancer. Additionally altered activity can contribute to the hormonal imbalances found in PCOS. Researchers have studied the interaction between Cyt 19 and breast cancer susceptibility proteins like BRCA1 seeking to understand their contributions to cancer's development and progression.
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Specifications

Form

Liquid

Additional notes

ab126694 is purified by conventional chromatography techniques.

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General info

Function

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed : 16407288, PubMed : 25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed : 16407288, PubMed : 25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed : 16407288, PubMed : 25997655).

Sequence similarities

Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

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Product protocols

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Target data

Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed : 16407288, PubMed : 25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed : 16407288, PubMed : 25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed : 16407288, PubMed : 25997655).
See full target information AS3MT
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