Recombinant Human CYTL1 protein (Fc Chimera)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

CYTL1 also known as cytokine-like protein 1 or C17orf99 is a protein that plays a role in various cellular processes. It has an approximate molecular mass of 19 kDa. Scientists have observed its expression in a wide range of tissues but it is particularly prominent in cartilage tissue and the immune system suggesting its involvement in functions related to these areas. CYTL1 does not appear to have a highly specific pattern of distribution as it is also found in the respiratory and cardiovascular systems making its mechanical functions intriguing for further research.

Biological function summary

CYTL1 acts as a regulator in processes like cell adhesion migration and immune responses. While it isn't part of a larger complex it interacts closely with other cellular components to modulate these activities. Within immune responses CYTL1 contributes by modulating cytokine signaling potentially influencing the behavior of immune cells in response to inflammatory signals. This regulation is essential in maintaining a balanced immune environment and preventing excessive inflammation.

Pathways

CYTL1's biological function connects to the NF-kB and JAK-STAT signaling pathways. In the NF-kB pathway CYTL1 indirectly influences the expression of genes involved in inflammation and apoptosis. While in the JAK-STAT pathway CYTL1 modulation aids in mediating the effects of cytokines and promotes immune cell proliferation and differentiation. Related proteins like IL-6 and TNF-alpha often interact within these pathways and CYTL1 acts as a modulating entity that helps fine-tune the cellular responses.

Associated diseases and disorders

Researchers have linked CYTL1 to potential roles in osteoarthritis and rheumatoid arthritis. In these conditions its expression level might affect cartilage integrity and inflammatory response. CYTL1 may interact with other proteins like MMPs (matrix metalloproteinases) in arthritis facilitating changes in cartilage matrix components. Understanding the precise role of CYTL1 in these diseases could offer new insights into therapeutic targets for mitigating joint degradation and inflammation.