Recombinant Human Cytoglobin protein (His tag N-Terminus)
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Recombinant Human Cytoglobin protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 190 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
STAP, CYGB, Cytoglobin, Histoglobin, Nitric oxygen dioxygenase CYGB, Nitrite reductase CYGB, Pseudoperoxidase CYGB, Stellate cell activation-associated protein, Superoxide dismutase CYGB, HGb, NOD
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Cytoglobin protein (AB97347)
3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This globin plays a role in cellular protective mechanisms. Cytoglobin participates in protecting cells from hypoxic and oxidative stress thereby contributing to oxygen homeostasis. Although it is not part of a known protein complex its ability to bind oxygen and reactive oxygen species indicates its significant role in mitigating cellular damage. By maintaining a balance of oxygen levels inside cells cytoglobin helps preserve cellular integrity under stressful conditions.
Pathways
Cytoglobin interacts in significant biological processes related to oxygen regulation. It is closely involved in the hypoxia response pathway where it aids in adapting cells to low oxygen environments. Cytoglobin operates alongside proteins such as hypoxia-inducible factors (HIFs) which help regulate gene expression in response to oxygen availability. It also plays a role in the oxidative stress response connecting to systems involving antioxidant proteins that help mitigate the effects of reactive oxygen species.
Specifications
Form
Liquid
Additional notes
ab97347 is purified using conventional chromatography techniques.
General info
Function
Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed : 11893755, PubMed : 12359339, PubMed : 15165856, PubMed : 19147491, PubMed : 20511233, PubMed : 28393874, PubMed : 28671819, PubMed : 29128400, PubMed : 33576020, PubMed : 34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed : 19147491, PubMed : 20511233, PubMed : 28393874, PubMed : 28671819). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed : 19147491, PubMed : 28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide (PubMed : 29128400). Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress (PubMed : 12359339, PubMed : 33576020, PubMed : 34930834). Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (PubMed : 11893755, PubMed : 15299006, PubMed : 20553503).
Sequence similarities
Belongs to the globin family.
Post-translational modifications
The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity.
Target data
Complementary Products
Product promise
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