Recombinant Human Cytokeratin 17 protein is a Human Full Length protein, in the 1 to 432 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
M T T S I R Q F T S S S S I K G S S G L G G G S S R T S C R L S G G L G A G S C R L G S A G G L G S T L G G S S Y S S C Y S F G S G G G Y G S S F G G V D G L L A G G E K A T M Q N L N D R L A S Y L D K V R A L E E A N T E L E V K I R D W Y Q R Q A P G P A R D Y S Q Y Y R T I E E L Q N K I L T A T V D N A N I L L Q I D N A R L A A D D F R T K F E T E Q A L R L S V E A D I N G L R R V L D E L T L A R A D L E M Q I E N L K E E L A Y L K K N H E E E M N A L R G Q V G G E I N V E M D A A P G V D L S R I P N E M R D Q Y E K M A E K N R K D A E D W F F S K T E E L N R E V A T N S E L V Q S G K S E I S E L R R T M Q A L E I E L Q S Q L S M K A S L E G N L A E T E N R Y C V Q L S Q I Q G L I G S V E E Q L A Q L R C E M E Q Q N Q E Y K I L L D V K T R L E Q E I A T Y R R L L E G E D A H L T Q Y K K E P V T T R Q V R T I V E E V Q D G K V I S S R E Q V H Q T T R
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes Recombinant protein. |
Select an associated product type
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
39.1, Cytokeratin-17, Keratin-17, CK-17, K17, KRT17
Recombinant Human Cytokeratin 17 protein is a Human Full Length protein, in the 1 to 432 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
M T T S I R Q F T S S S S I K G S S G L G G G S S R T S C R L S G G L G A G S C R L G S A G G L G S T L G G S S Y S S C Y S F G S G G G Y G S S F G G V D G L L A G G E K A T M Q N L N D R L A S Y L D K V R A L E E A N T E L E V K I R D W Y Q R Q A P G P A R D Y S Q Y Y R T I E E L Q N K I L T A T V D N A N I L L Q I D N A R L A A D D F R T K F E T E Q A L R L S V E A D I N G L R R V L D E L T L A R A D L E M Q I E N L K E E L A Y L K K N H E E E M N A L R G Q V G G E I N V E M D A A P G V D L S R I P N E M R D Q Y E K M A E K N R K D A E D W F F S K T E E L N R E V A T N S E L V Q S G K S E I S E L R R T M Q A L E I E L Q S Q L S M K A S L E G N L A E T E N R Y C V Q L S Q I Q G L I G S V E E Q L A Q L R C E M E Q Q N Q E Y K I L L D V K T R L E Q E I A T Y R R L L E G E D A H L T Q Y K K E P V T T R Q V R T I V E E V Q D G K V I S S R E Q V H Q T T R
Full Length
73.26 kDa
1 to 432
Recombinant
Liquid
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Belongs to the intermediate filament family.
Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
Cytokeratin 17 often called K17 or keratin 17 is a type I intermediate filament protein with a molecular weight of approximately 46 kDa. It forms part of the cytoskeleton in epithelial cells and is notably present in the basal cells of epithelial tissues including the skin hair follicles and the lining of internal organs. Due to its specific expression pattern K17 serves as a useful biomarker in various research and clinical settings.
The roles of K17 extend beyond mere structural support. This protein contributes to cellular processes such as proliferation tissue repair and the regulation of immune responses. K17 often forms a complex with its partner keratin 6 enabling structural stability and resilience in epithelial cells. Its presence influences the behavior of the cells in skin and other epithelial-lined organs.
K17 participates in key pathways related to skin biology and inflammation notably the Wnt/β-catenin and NF-κB signaling pathways. These pathways connect K17 to cellular processes like growth differentiation and inflammation. In particular keratin 6 is another important protein in these cascades closely interacting with K17 in maintenance and repair processes within epithelial tissues.
K17 has been implicated in psoriasis and certain types of cancer such as cervical and breast cancer. In psoriasis an inflammatory skin condition K17 interacts with pro-inflammatory cytokines contributing to the hyperproliferative state of the skin. Its overexpression serves as a marker in diagnosing and understanding the severity of these disorders highlighting its relationship with keratin 6 which is similarly upregulated in psoriatic lesions and certain tumors. These associations make K17 a significant focus for therapeutic targeting and diagnostic applications.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
12.5% SDS-PAGE showing ab116974 at approximately 73.26kDa.
Stained with Coomassie Blue.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com