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Recombinant Human Cytokeratin 17 protein is a Human Full Length protein, in the 1 to 432 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

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Images

SDS-PAGE - Recombinant Human Cytokeratin 17 protein (AB116974), expandable thumbnail

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

SDS-PAGE, ELISA, WB

Biologically active

No

Amino acid sequence

M T T S I R Q F T S S S S I K G S S G L G G G S S R T S C R L S G G L G A G S C R L G S A G G L G S T L G G S S Y S S C Y S F G S G G G Y G S S F G G V D G L L A G G E K A T M Q N L N D R L A S Y L D K V R A L E E A N T E L E V K I R D W Y Q R Q A P G P A R D Y S Q Y Y R T I E E L Q N K I L T A T V D N A N I L L Q I D N A R L A A D D F R T K F E T E Q A L R L S V E A D I N G L R R V L D E L T L A R A D L E M Q I E N L K E E L A Y L K K N H E E E M N A L R G Q V G G E I N V E M D A A P G V D L S R I P N E M R D Q Y E K M A E K N R K D A E D W F F S K T E E L N R E V A T N S E L V Q S G K S E I S E L R R T M Q A L E I E L Q S Q L S M K A S L E G N L A E T E N R Y C V Q L S Q I Q G L I G S V E E Q L A Q L R C E M E Q Q N Q E Y K I L L D V K T R L E Q E I A T Y R R L L E G E D A H L T Q Y K K E P V T T R Q V R T I V E E V Q D G K V I S S R E Q V H Q T T R

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

ELISA

Reactivity

Reacts

Dilution info

-

Notes

-

Application

WB

Reactivity

Reacts

Dilution info

-

Notes

Recombinant protein.

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Alternative names

Recommended products

Recombinant Human Cytokeratin 17 protein is a Human Full Length protein, in the 1 to 432 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

Key facts

Expression system

Wheat germ

Applications

SDS-PAGE, ELISA, WB

Accession
Q04695-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione

Sequence info

Amino acid sequence

M T T S I R Q F T S S S S I K G S S G L G G G S S R T S C R L S G G L G A G S C R L G S A G G L G S T L G G S S Y S S C Y S F G S G G G Y G S S F G G V D G L L A G G E K A T M Q N L N D R L A S Y L D K V R A L E E A N T E L E V K I R D W Y Q R Q A P G P A R D Y S Q Y Y R T I E E L Q N K I L T A T V D N A N I L L Q I D N A R L A A D D F R T K F E T E Q A L R L S V E A D I N G L R R V L D E L T L A R A D L E M Q I E N L K E E L A Y L K K N H E E E M N A L R G Q V G G E I N V E M D A A P G V D L S R I P N E M R D Q Y E K M A E K N R K D A E D W F F S K T E E L N R E V A T N S E L V Q S G K S E I S E L R R T M Q A L E I E L Q S Q L S M K A S L E G N L A E T E N R Y C V Q L S Q I Q G L I G S V E E Q L A Q L R C E M E Q Q N Q E Y K I L L D V K T R L E Q E I A T Y R R L L E G E D A H L T Q Y K K E P V T T R Q V R T I V E E V Q D G K V I S S R E Q V H Q T T R

Accession

Q04695

Protein length

Full Length

Predicted molecular weight

73.26 kDa

Amino acids

1 to 432

Nature

Recombinant

Specifications

Form

Liquid

General info

Function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Sequence similarities

Belongs to the intermediate filament family.

Post-translational modifications

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Cytokeratin 17 often called K17 or keratin 17 is a type I intermediate filament protein with a molecular weight of approximately 46 kDa. It forms part of the cytoskeleton in epithelial cells and is notably present in the basal cells of epithelial tissues including the skin hair follicles and the lining of internal organs. Due to its specific expression pattern K17 serves as a useful biomarker in various research and clinical settings.

Biological function summary

The roles of K17 extend beyond mere structural support. This protein contributes to cellular processes such as proliferation tissue repair and the regulation of immune responses. K17 often forms a complex with its partner keratin 6 enabling structural stability and resilience in epithelial cells. Its presence influences the behavior of the cells in skin and other epithelial-lined organs.

Pathways

K17 participates in key pathways related to skin biology and inflammation notably the Wnt/β-catenin and NF-κB signaling pathways. These pathways connect K17 to cellular processes like growth differentiation and inflammation. In particular keratin 6 is another important protein in these cascades closely interacting with K17 in maintenance and repair processes within epithelial tissues.

Associated diseases and disorders

K17 has been implicated in psoriasis and certain types of cancer such as cervical and breast cancer. In psoriasis an inflammatory skin condition K17 interacts with pro-inflammatory cytokines contributing to the hyperproliferative state of the skin. Its overexpression serves as a marker in diagnosing and understanding the severity of these disorders highlighting its relationship with keratin 6 which is similarly upregulated in psoriatic lesions and certain tumors. These associations make K17 a significant focus for therapeutic targeting and diagnostic applications.

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1 product image

  • SDS-PAGE - Recombinant Human Cytokeratin 17 protein (ab116974), expandable thumbnail

    SDS-PAGE - Recombinant Human Cytokeratin 17 protein (ab116974)

    12.5% SDS-PAGE showing ab116974 at approximately 73.26kDa.
    Stained with Coomassie Blue.

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Product protocols

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