Recombinant Human DARC protein is a Human Full Length protein, in the 1 to 336 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M G N C L H R A E L S P S T E N S S Q L D F E D V W N S S Y G V N D S F P D G D Y G A N L E A A A P C H S C N L L D D S A L P F F I L T S V L G I L A S S T V L S M L F R P L F R W Q L C P G W P V L A Q L A V G S A L F S I V V P V L A P G L G S T R S S A L C S L G Y C V W Y G S A F A Q A L L L G C H A S L G H R L G A G Q V P G L T L G L T V G I W G V A A L L T L P V T L A S G A S G G L C T L I Y S T E L K A L Q A T H T V A C L A I F V L L P L G L F G A K G L K K A L G M G P G P W M N I L W A W F I F W W P H G V V L G L D F L V R S K L L L L S T C L A Q Q A L D L L L N L A E A L A I L H C V A T P L L L A L F C H Q A T R T L L P S L P L P E G W F S H L D T L G S K S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Alternative names
CD234, DARC, FY, GPD, ACKR1, Atypical chemokine receptor 1, Duffy antigen/chemokine receptor, Fy glycoprotein, Glycoprotein D, Plasmodium vivax receptor, GpFy
Recommended products
Recombinant Human DARC protein is a Human Full Length protein, in the 1 to 336 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q16570-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M G N C L H R A E L S P S T E N S S Q L D F E D V W N S S Y G V N D S F P D G D Y G A N L E A A A P C H S C N L L D D S A L P F F I L T S V L G I L A S S T V L S M L F R P L F R W Q L C P G W P V L A Q L A V G S A L F S I V V P V L A P G L G S T R S S A L C S L G Y C V W Y G S A F A Q A L L L G C H A S L G H R L G A G Q V P G L T L G L T V G I W G V A A L L T L P V T L A S G A S G G L C T L I Y S T E L K A L Q A T H T V A C L A I F V L L P L G L F G A K G L K K A L G M G P G P W M N I L W A W F I F W W P H G V V L G L D F L V R S K L L L L S T C L A Q Q A L D L L L N L A E A L A I L H C V A T P L L L A L F C H Q A T R T L L P S L P L P E G W F S H L D T L G S K S
- Accession
- Q16570
- Protein length
- Full Length
- Predicted molecular weight
- 63.07 kDa
- Amino acids
- 1 to 336
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
- Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.
- Subcellular localisation
- Early endosome, Recycling endosome
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human DARC protein (ab114557)
12.5% SDS-PAGE Stained with Coomassie Blue
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
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