Recombinant human DcR1 protein (His tag) is a Human Fragment protein, in the 1 to 235 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
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- EMBO reports 23:e541332022Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJohannes Höfle,Timo Trenkner,Nadja Kleist,Vera Schwane,Sarah Vollmers,Bryan Barcelona,Annika Niehrs,Pia Fittje,Van Hung Huynh-Tran,Jürgen Sauter,Alexander H Schmidt,Sven Peine,Angelique Hoelzemer,Laura Richert,Marcus Altfeld,Christian KörnerPubMed 35758160
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
Amino acid sequence
M A R I P K T L K F V V V I V A V L L P V L A Y S A T T A R Q E E V P Q Q T V A P Q Q Q R H S F K G E E C P A G S H R S E H T G A C N P C T E G V D Y T N A S N N E P S C F P C T V C K S D Q K H K S S C T M T R D T V C Q C K E G T F R N E N S P E M C R K C S R C P S G E V Q V S N C T S W D D I Q C V E E F G A N A T V E T P A A E E T M N T S P G T P A P A A E E T M N T S P G T P A P A A E E T M T T S P G T P A P A A E E T M T T S P G T P A P A A E E T M I T S P G T P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Alternative names
CD263, DCR1, LIT, TRAILR3, TRID, UNQ321/PRO366, TNFRSF10C, Tumor necrosis factor receptor superfamily member 10C, Antagonist decoy receptor for TRAIL/Apo-2L, Decoy TRAIL receptor without death domain, Decoy receptor 1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor without an intracellular domain, DcR1, TRAIL receptor 3, TRAIL-R3
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Recombinant human DcR1 protein (His tag) is a Human Fragment protein, in the 1 to 235 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
- Biological activity
- Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10C at 10 μg/mL (100 μL/well) can bind biotinylated human TNFSF10, the EC50 of biotinylated human TNFSF10 is 0.1-0.7 μg/mL.
- Accession
- O14798-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A R I P K T L K F V V V I V A V L L P V L A Y S A T T A R Q E E V P Q Q T V A P Q Q Q R H S F K G E E C P A G S H R S E H T G A C N P C T E G V D Y T N A S N N E P S C F P C T V C K S D Q K H K S S C T M T R D T V C Q C K E G T F R N E N S P E M C R K C S R C P S G E V Q V S N C T S W D D I Q C V E E F G A N A T V E T P A A E E T M N T S P G T P A P A A E E T M N T S P G T P A P A A E E T M T T S P G T P A P A A E E T M T T S P G T P A P A A E E T M I T S P G T P
- Accession
- O14798
- Protein length
- Fragment
- Predicted molecular weight
- 23.6 kDa
- Amino acids
- 1 to 235
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
- Post-translational modifications
N-glycosylated and O-glycosylated.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Product promise
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Full details and terms and conditions can be found here:
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2 product images
Functional Studies - Recombinant human DcR1 protein (His tag) (ab276266)
Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10C at 10 μg/mL (100 μL/well) can bind biotinylated human TNFSF10, the EC50 of biotinylated human TNFSF10 is 0.1-0.7 μg/mL.
SDS-PAGE - Recombinant human DcR1 protein (His tag) (ab276266)
SDS-PAGE analysis of ab276266
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