Recombinant Human DDI1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DDI1 or DNA-damage inducible 1 homolog is a protease involved in protein degradation and cellular stress responses. This protein with a molecular weight of approximately 50 kDa functions through unique retroviral protease-like domain. DDI1 is expressed in various tissues with higher levels observed in certain cancerous tissues. Due to its proteolytic activity DDI1 plays a role in degrading ubiquitinated substrates unlike other proteases in its family.

Biological function summary

DDI1 influences several cellular processes involving protein homeostasis and stress response. It forms part of a larger protein complex engaged in responding to DNA damage and ensuring proper protein turnover. By interacting with other stress-related proteins DDI1 aids in maintaining cellular health under conditions that cause DNA damage and proteotoxic stress.

Pathways

Researchers have identified that DDI1 plays roles in the ubiquitin-proteasome system and DNA damage response pathways. In the context of the ubiquitin-proteasome pathway DDI1 cooperates with proteins such as ubiquitin ligases to target specific substrates for degradation. Within DNA damage response pathways DDI1 interacts with proteins like RAD23 aiding in the repair of damaged DNA and ensuring genomic stability.

Research indicates that aberrant expression or function of DDI1 associates with certain types of cancer and neurodegenerative diseases. For example DDI1 levels affect the progression of prostate cancer often seen in interplay with proteasome machinery proteins. Similarly its relation to neurodegenerative diseases involves pathways intertwined with proteins like polyglutamine aggregates as disrupted protein homeostasis contributes to these disorders.