Recombinant Human DDX56/DDX21 protein (denatured)
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Recombinant Human DDX56/DDX21 protein (denatured) is a Human Full Length protein, in the 1 to 547 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
DDX21, NOH61, DDX56, Probable ATP-dependent RNA helicase DDX56, ATP-dependent 61 kDa nucleolar RNA helicase, DEAD box protein 21, DEAD box protein 56
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human DDX56/DDX21 protein (denatured) (AB171485)
15% SDS-PAGE analysis of ab171485 (3µg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DDX56 acts in the regulation of ribosome assembly and ribosomal RNA processing. This protein is involved in the transcription and maturation of pre-rRNA an important step in ribosome biogenesis. DDX56 forms part of the small subunit (SSU) processome complex which contains various proteins necessary for early stages of ribosome assembly. The SSU processome is essential for the processing of primary rRNA transcripts into 18S rRNA.
Pathways
DDX56 is important in ribosome biogenesis and RNA transcription. It interacts with components of the RNA polymerase I pathway which is responsible for the transcription of rRNA genes. DDX56 also associates with the snoRNP complexes involved in the modification and processing of rRNA. Its activity affects proteins like fibrillarin and U3 snoRNA which are required for rRNA processing and ribosome assembly.
Specifications
Form
Liquid
General info
Function
Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed : 31340999, PubMed : 33789112). Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed : 33789112). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 (PubMed : 31340999). Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 (PubMed : 31340999). May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.. (Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection.. (Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon.. (Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation.
Sequence similarities
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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