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AB105597

Recombinant Human DECR1 protein

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Recombinant Human DECR1 protein is a Human Full Length protein, in the 35 to 335 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

DECR, SDR18C1, DECR1, Short chain dehydrogenase/reductase family 18C member 1, 4-enoyl-CoA reductase [NADPH]

1 Images
SDS-PAGE - Recombinant Human DECR1 protein (AB105597)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human DECR1 protein (AB105597)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q16698

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS","proteinLength":"Full Length","predictedMolecularWeight":"34.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":335,"aminoAcidStart":35,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16698","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DECR1 also known as 24-Dienoyl-CoA Reductase 1 is an enzyme important in fatty acid metabolism. Its mass is approximately 35 kDa. It catalyzes the NADP-dependent reduction of 24-dienoyl-CoA to trans-enoyl-CoA an important step in the beta-oxidation of unsaturated fatty acids. DECR1 is expressed in many tissues but it shows especially high levels in the liver and heart. This expression pattern suggests its significant role in tissues where active lipid metabolism occurs.
Biological function summary

DECR1 supports the breakdown and energy release from unsaturated fatty acids. The enzymatic activity of DECR1 helps maintain cellular energy balance and overall metabolic homeostasis. It does not operate as part of a larger complex but it functions individually to catalyze reactions vital for energy production in cells. By converting dienoyl-CoA substrates into more readily oxidizable forms DECR1 facilitates energy production from dietary lipids and stored fat.

Pathways

DECR1 is integral to the beta-oxidation metabolic pathway which is important for energy production particularly in fasting conditions. This enzyme specifically acts on polyunsaturated fatty acids processing them within the mitochondrial matrix. DECR1's activity relates to similar enzymes like mitochondrial acyl-CoA dehydrogenase family members which work in tandem within the beta-oxidation cycle to ensure efficient fatty acid degradation.

DECR1 has significant connections to metabolic conditions particularly those involving lipid metabolism. DECR1 deficiency or mutations can lead to disorders such as 24-dienoyl-CoA reductase deficiency characterized by progressive encephalopathy and muscular weakness. DECR1's role in lipid metabolism also implicates it in conditions like non-alcoholic fatty liver disease (NAFLD). In NAFLD disrupted lipid metabolism links DECR1 to mitochondrial enzymes like CPT2 which also play roles in fatty acid oxidation.
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Specifications

Form

Liquid

Additional notes

ab105597 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.

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General info

Function

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

Subcellular localisation

Mitochondrion

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Product protocols

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Target data

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
See full target information DECR1
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