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AB140059

Recombinant Human DEDD protein (denatured)

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Recombinant Human DEDD protein (denatured) is a Human Full Length protein, in the 1 to 318 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

DEDPRO1, DEFT, KE05, DEDD, Death effector domain-containing protein, DEDPro1, Death effector domain-containing testicular molecule, FLDED-1

1 Images
SDS-PAGE - Recombinant Human DEDD protein (denatured) (AB140059)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human DEDD protein (denatured) (AB140059)

15% SDS-PAGE analysis of ab140059 (3μg)

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75618

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAGLKRRASQVWPEEHGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKRRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGPQMCSKRPARGRATLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP","proteinLength":"Full Length","predictedMolecularWeight":"38.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":318,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75618","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DEDD also known as death effector domain-containing protein weighs about 35 kDa. Its expression can be found in various tissues including the thymus spleen and lymph nodes. This protein plays a role in apoptosis regulation interacting with other proteins to influence cell survival. Researchers have studied DEDD extensively for its importance in cell death mechanisms.
Biological function summary

DEDD participates in apoptosis by forming complexes with caspases which are critical proteins in cell death processes. This protein contributes to the intrinsic pathway of apoptosis where it plays a role in dismantling cellular structures. Moreover DEDD interacts with nuclear proteins further implicating it in cell cycle regulation and maintaining genomic stability.

Pathways

DEDD functions within the apoptotic pathway alongside caspase-3 and caspase-6. DEDD's interaction with caspase-8 is particularly important as it influences the initiation of apoptosis. Additionally in the context of the extrinsic pathway DEDD associates with the death-inducing signaling complex (DISC) highlighting its role in death receptor-mediated apoptosis.

DEDD's altered expression links to cancer and autoimmune diseases. In some cancers reduced DEDD levels can correspond with tumor progression due to impaired apoptosis. Meanwhile in autoimmune disorders dysregulation of apoptosis involving DEDD and Fas-associated proteins can provoke abnormal immune responses. These associations between DEDD and key proteins like caspase family members highlight its relevance in medical research.
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Specifications

Form

Liquid

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General info

Function

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).

Post-translational modifications

Exists predominantly in a mono- or diubiquitinated form.

Subcellular localisation

Nucleus

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Product protocols

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Target data

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).
See full target information DEDD
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