Recombinant Human DEFB116 protein (denatured)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

DEFB116 also known as Beta-defensin 116 is a small antimicrobial peptide involved in the innate immune defense. It has a molecular weight of about 9.5 kDa. Researchers have identified its expression primarily in epithelial tissues including testis and prostate. DEFB116 belongs to a family of beta-defensins that share structural similarities and common motifs important for their function in host defense.

Biological function summary

DEFB116 acts as part of the body's first line of defense by contributing to antimicrobial and anti-inflammatory activity. It does not form part of a larger protein complex functioning independently to disrupt microbial membranes and neutralize pathogens. DEFB116 also plays a role in modulating the immune response by recruiting and activating immune cells like macrophages and dendritic cells.

Pathways

The action of DEFB116 spans the innate immune signaling and inflammatory response pathways. It interacts with components of the Toll-like receptor (TLR) and NF-kB signaling pathways essential for detecting and responding to microbial infections. DEFB116 shares relationships with other beta-defensins and cytokines like interleukin-1β which mediates inflammation and immune responses.

Associated diseases and disorders

DEFB116 has been implicated in infertility and chronic prostatitis. Its role in fertility is particularly linked to sperm motility and integrity with deficits suggesting connections to male infertility. Chronic prostatitis also shows associations with altered DEFB116 expression which could relate to inflammation and infection control. In these conditions alterations in DEFB116 levels might interact with other defensins to affect disease outcomes and inflammatory states.