Recombinant Human Deformed Epidermal Autoregulatory Factor 1 protein is a Human Full Length protein, in the 2 to 565 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, FuncS.
M A S M T G G Q Q M G R G H H H H H H E N L Y F Q G E D S D S A A K Q L G L A E A A A V A A A A A V A A A A A A A A G G E A E E P V L S R D E D S E E D A D S E A E R E T P R V T A V A V M A A E P G H M D M G A E A L P G P D E A A A A A A F A E V T T V T V A N V G A A A D N V F T T S V A N A A S I S G H V L S G R T A L Q I G D S L N T E K A T L I V V H T D G S I V E T T G L K G P A A P L T P G P Q S P P T P L A P G Q E K G G T K Y N W D P S V Y D S E L P V R C R N I S G T L Y K N R L G S G G R G R C I K Q G E N W Y S P T E F E A M A G R A S S K D W K R S I R Y A G R P L Q C L I Q D G I L N P H A A S C T C A A C C D D M T L S G P V R L F V P Y K R R K K E N E L P T T P V K K D S P K N I T L L P A T A A T T F T V T P S G Q I T T S G A L T F D R A S T V E A T A V I S E S P A Q G D V F A G A T V Q E A S V Q P P C R A S H P E P H Y P G Y Q D S C Q I A P F P E A A L P T S H P K I V L T S L P A L A V P P P T P T K A A P P A L V N G L E L S E P R S W L Y L E E M V N S L L N T A Q Q L K T L F E Q A K H A S T Y R E A A T N Q A K I H A D A E R K E Q S C V N C G R E A M S E C T G C H K V N Y C S T F C Q R K D W K D H Q H I C G Q S A A V T V Q A D E V H V A E S V M E K V T V
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes It may be used for in vitro Deformed Epidermal Autoregulatory Factor 1 mediated gene transcription regulation for neuronal differentiation study. It may be used as specific protein substrate for kinase and ubiquitin (Sumo pathway) related enzyme functional screening assays. It may be used for Deformed Epidermal Autoregulatory Factor 1 protein-protein interaction mapping. It may be used as immunogen for specific antibody production. |
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.
SPN, ZMYND5, DEAF1, Deformed epidermal autoregulatory factor 1 homolog, Nuclear DEAF-1-related transcriptional regulator, Suppressin, Zinc finger MYND domain-containing protein 5, NUDR
Recombinant Human Deformed Epidermal Autoregulatory Factor 1 protein is a Human Full Length protein, in the 2 to 565 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, FuncS.
pH: 8
Constituents: 0.32% Tris HCl
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.
May be phosphorylated by DNA-PK complex in a DNA independent manner (in vitro).
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com