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AB276581

Recombinant Human DEGA protein (His tag)

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Recombinant Human DEGA protein (His tag) is a Human Fragment protein, in the 1 to 398 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

ALI1, AMIGO2, Amphoterin-induced protein 2, AMIGO-2, Alivin-1, Differentially expressed in gastric adenocarcinomas, DEGA

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SDS-PAGE - Recombinant Human DEGA protein (His tag) (AB276581)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human DEGA protein (His tag) (AB276581)

SDS-PAGE analysis of ab276581

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q86SJ2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Complementary Products

Primary Antibodies

AB84416

Anti-DEGA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DEGA antibody (AB84416)

  • 3
  • 2
Assay Kits

AB313506

Human DEGA ELISA Kit

Sandwich ELISA - Human DEGA ELISA Kit (AB313506)

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Proteins & Peptides

AB236180

Recombinant Human Proteasome 20S LMP7 protein (Tagged)

SDS-PAGE - Recombinant Human Proteasome 20S LMP7 protein (Tagged) (AB236180)

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Proteins & Peptides

AB152075

Recombinant Human Carboxypeptidase A protein

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSRSHAHEAFNT","proteinLength":"Fragment","predictedMolecularWeight":"42.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":398,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q86SJ2","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DEGA protein also known as DEGA-1 functions mechanically as a transmembrane protein involved in cellular adhesion. It has a mass of approximately 55 kDa and expresses widely in epithelial tissues where cellular interactions requiring adhesion are important for tissue integrity. DEGA is present in various cell types indicating its broad physiological relevance across tissues.
Biological function summary

This protein plays a role in modulating cell adhesion dynamics and contributes to tissue organization and stability. It forms part of adhesion complexes at the cellular surface interacting with cytoskeletal elements. Through these complexes DEGA helps maintain mechanical stability and signaling within epithelial cells making it an important component in tissue maintenance and repair.

Pathways

DEGA participates in cellular adhesion and signaling pathways essential for maintaining epithelial integrity. It interacts with proteins such as E-cadherin a well-known adhesion molecule forming a network that reinforces adhesion. This protein also integrates signals for pathway regulation playing a critical role in maintaining homeostasis in the epithelial layer.

DEGA is linked to epithelial-related conditions such as carcinomas where altered adhesion contributes to disease progression. It interacts with proteins involved in tumorigenesis such as E-cadherin and beta-catenin. The loss or dysfunction of DEGA can lead to disrupted cell adhesion contributing to the invasive characteristics of cancerous cells highlighting its importance in disease pathology.
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Specifications

Form

Lyophilized

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General info

Function

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Sequence similarities

Belongs to the immunoglobulin superfamily. AMIGO family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
See full target information AMIGO2
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Product promise

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