Recombinant Human DEGA protein (His tag) is a Human Fragment protein, in the 1 to 398 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
M S L R V H T L P T L L G A V V R P G C R E L L C L L M I T V T V G P G A S G V C P T A C I C A T D I V S C T N K N L S K V P G N L F R L I K R L D L S Y N R I G L L D S E W I P V S F A K L N T L I L R H N N I T S I S T G S F S T T P N L K C L D L S S N K L K T V K N A V F Q E L K V L E V L L L Y N N H I S Y L D P S A F G G L S Q L Q K L Y L S G N F L T Q F P M D L Y V G R F K L A E L M F L D V S Y N R I P S M P M H H I N L V P G K Q L R G I Y L H G N P F V C D C S L Y S L L V F W Y R R H F S S V M D F K N D Y T C R L W S D S R H S R Q V L L L Q D S F M N C S D S I I N G S F R A L G F I H E A Q V G E R L M V H C D S K T G N A N T D F I W V G P D N R L L E P D K E M E N F Y V F H N G S L V I E S P R F E D A G V Y S C I A M N K Q R L L N E T V D V T I N V S N F T V S R S H A H E A F N T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Alternative names
Amphoterin-induced protein 2, AMIGO-2, Alivin-1, Differentially expressed in gastric adenocarcinomas, DEGA, AMIGO2, ALI1
Recommended products
Recombinant Human DEGA protein (His tag) is a Human Fragment protein, in the 1 to 398 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Alternative names
Amphoterin-induced protein 2, AMIGO-2, Alivin-1, Differentially expressed in gastric adenocarcinomas, DEGA, AMIGO2, ALI1
Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- Q86SJ2-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
M S L R V H T L P T L L G A V V R P G C R E L L C L L M I T V T V G P G A S G V C P T A C I C A T D I V S C T N K N L S K V P G N L F R L I K R L D L S Y N R I G L L D S E W I P V S F A K L N T L I L R H N N I T S I S T G S F S T T P N L K C L D L S S N K L K T V K N A V F Q E L K V L E V L L L Y N N H I S Y L D P S A F G G L S Q L Q K L Y L S G N F L T Q F P M D L Y V G R F K L A E L M F L D V S Y N R I P S M P M H H I N L V P G K Q L R G I Y L H G N P F V C D C S L Y S L L V F W Y R R H F S S V M D F K N D Y T C R L W S D S R H S R Q V L L L Q D S F M N C S D S I I N G S F R A L G F I H E A Q V G E R L M V H C D S K T G N A N T D F I W V G P D N R L L E P D K E M E N F Y V F H N G S L V I E S P R F E D A G V Y S C I A M N K Q R L L N E T V D V T I N V S N F T V S R S H A H E A F N T
- Accession
- Protein length
Fragment
- Predicted molecular weight
42.3 kDa
- Amino acids
1 to 398
- Nature
Recombinant
- Tags
His tag C-Terminus
Specifications
- Form
Lyophilized
General info
- Function
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
- Sequence similarities
Belongs to the immunoglobulin superfamily. AMIGO family.
- Subcellular localisation
Nucleus
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The DEGA protein also known as DEGA-1 functions mechanically as a transmembrane protein involved in cellular adhesion. It has a mass of approximately 55 kDa and expresses widely in epithelial tissues where cellular interactions requiring adhesion are important for tissue integrity. DEGA is present in various cell types indicating its broad physiological relevance across tissues.
- Biological function summary
This protein plays a role in modulating cell adhesion dynamics and contributes to tissue organization and stability. It forms part of adhesion complexes at the cellular surface interacting with cytoskeletal elements. Through these complexes DEGA helps maintain mechanical stability and signaling within epithelial cells making it an important component in tissue maintenance and repair.
- Pathways
DEGA participates in cellular adhesion and signaling pathways essential for maintaining epithelial integrity. It interacts with proteins such as E-cadherin a well-known adhesion molecule forming a network that reinforces adhesion. This protein also integrates signals for pathway regulation playing a critical role in maintaining homeostasis in the epithelial layer.
- Associated diseases and disorders
DEGA is linked to epithelial-related conditions such as carcinomas where altered adhesion contributes to disease progression. It interacts with proteins involved in tumorigenesis such as E-cadherin and beta-catenin. The loss or dysfunction of DEGA can lead to disrupted cell adhesion contributing to the invasive characteristics of cancerous cells highlighting its importance in disease pathology.
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SDS-PAGE - Recombinant Human DEGA protein (His tag) (ab276581)
SDS-PAGE analysis of ab276581
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