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AB165196

Recombinant Human DEGS2 protein

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Recombinant Human DEGS2 protein is a Human Full Length protein, in the 1 to 323 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C14orf66, DEGS2, Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2, Degenerative spermatocyte homolog 2, Sphingolipid 4-desaturase, Sphingolipid C4-monooxygenase

1 Images
SDS-PAGE - Recombinant Human DEGS2 protein (AB165196)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human DEGS2 protein (AB165196)

ab165196 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q6QHC5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGNSASRSDFEWVYTDQPHTQRRKEILAKYPAIKALMRPDPRLKWAVLVLVLVQMLTCWLVRGLAWRWLLFWAYAFGGCVNHSLTLAIHDISHNAAFGTGRAARNRWLAVFANLPVGVPYAASFKKYHVDHHRYLGGDGLDVDVPTRLEGWFFCTPARKLLWLVLQPFFYSLRPLCVHPKAVTRMEVLNTLVQLAADLAIFALWGLKPVVYLLASSFLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGYNLPLVRKIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYARVKRVYRLAKDGL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":323,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6QHC5","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The DEGS2 protein also known as delta(4)-desaturase sphingolipid 2 plays a mechanical role in lipid metabolism specifically in the desaturation process of sphingolipids. DEGS2 has a molecular mass of around 37 kDa. The protein is expressed in various tissues with notable levels in the liver and skin. Its enzymatic activity converts dihydroceramide to ceramide important steps in the synthesis of sphingolipids molecules essential for cell membrane structure and function.
Biological function summary

DEGS2 participates in the biosynthesis of sphingolipids a process important for the maintenance of cellular structure and signaling. It does not form part of a larger enzymatic complex and acts independently in its function. Sphingolipids are involved in important cellular processes such as apoptosis and cell growth which influence cell fate and communication. The role of DEGS2 in sphingolipid metabolism impacts how cells maintain their integrity and react to changes in their environment.

Pathways

The DEGS2 protein interacts with the sphingolipid metabolic pathway and the apoptosis signaling pathway. It plays a role in the conversion steps of sphingolipid biosynthesis alongside other proteins such as DEGS1 which also participates in the desaturation of dihydroceramide. In apoptosis DEGS2’s production of ceramide acts as a signaling molecule that can influence cell death pathways thereby connecting lipid metabolism with cell survival and death mechanisms.

DEGS2 activity relates to sphingolipidoses and skin disorders such as ichthyosis. Abnormal DEGS2 function can lead to disrupted ceramide levels which affects skin barrier integrity and may contribute to the pathology of these conditions. Furthermore this protein’s involvement in sphingolipid metabolism connects it to DEGS1 as changes in the balance and concentrations of sphingolipids can have cascading effects on conditions related to lipid storage and management potentially influencing the progression of metabolic and neurological diseases.
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Specifications

Form

Liquid

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General info

Function

Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.

Sequence similarities

Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.

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Product protocols

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Target data

Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
See full target information DEGS2
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