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AB113155

Recombinant Human DERA protein

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Recombinant Human DERA protein is a Human Full Length protein, in the 1 to 318 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CGI-26, DERA, Deoxyribose-phosphate aldolase, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase

1 Images
SDS-PAGE - Recombinant Human DERA protein (AB113155)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human DERA protein (AB113155)

15% SDS-PAGE showing ab113155 (3 μg) at approximately 37.3 kDa.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9Y315

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQAAWLLKAVTFIDLTTLSGDDTSSNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVKALKAAGCNIPVASVAAGFPAGQTHLKTRLEEIRLAVEDGATEIDVVINRSLVLTGQWEALYDEIRQFRKACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQIYHHVTGRYAAYHDLPMS","proteinLength":"Full Length","predictedMolecularWeight":"37.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":318,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y315","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DERA also known as deoxyribose-phosphate aldolase is an enzyme involved in the catalysis of the reversible cleavage of deoxyribose-5-phosphate into acetaldehyde and glyceraldehyde-3-phosphate. This enzyme has a molecular weight of approximately 32 kDa. DERA is expressed in various tissues with notable levels in the liver and kidney. The presence of DERA in these tissues suggests it may have significant functions related to cellular processes in these organs.
Biological function summary

The deoxyribose-phosphate aldolase plays an important role in deoxyribonucleotide metabolism and the salvage pathways. It operates as a part of nucleotide turnover by handling deoxyribose sugars that arise during DNA degradation. While not part of a larger multi-enzyme complex its function influences nucleotide availability which can impact DNA repair and replication. This has downstream effects on cellular proliferation and maintenance of genetic integrity.

Pathways

Deoxyribose-phosphate aldolase is integral to the pentose phosphate pathway providing it with substrates derived from deoxyribonucleotide breakdown. This pathway is important in maintaining cellular redox balance and providing ribose sugars for nucleotide synthesis. DERA is connected with aldolase class I and II enzymes which share similar substrate cleavage activities. Its role supports the oxidative branch of the pentose phosphate pathway influencing cellular metabolism and energy yielding processes.

Decreased or malfunctioning DERA activity has been linked to conditions such as cancer and neurodegenerative diseases. Impaired deoxyribose metabolism could cause an accumulation of toxic intermediates impacting neural and cellular function. DERA's interaction with DNA Pol β a protein involved in base excision repair further highlights its connection to cancer. Abnormal DERA expression may lead to insufficient nucleotide salvage contributing to genomic instability common in malignancies.
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Specifications

Form

Liquid

Additional notes

ab113155 was purified using conventional chromatography techniques.

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General info

Function

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Sequence similarities

Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.
See full target information DERA
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