Recombinant Human Dexras1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dexras1 also known as DEXRAS1 or RHES is a small GTPase with a molecular weight of approximately 33 kDa. This protein is part of the Ras superfamily specifically the Ras-Dex subfamily involved in signal transduction. It has a strong expression in the brain particularly in the striatum and other areas with high neuronal activity. Dexras1 acts as a molecular switch by cycling between an active GTP-bound state and an inactive GDP-bound state modulating various intracellular signaling pathways.

Biological function summary

Small GTP-binding proteins like Dexras1 participate in intracellular signaling through interactions with other proteins. Dexras1 plays a role in the regulation of circadian rhythms possibly through interaction with the photic entrainment of the circadian clock. Additionally it contributes to the modulation of neuronal signaling and neurotransmitter release potentially by complex formation with other signaling molecules. Research also suggests its involvement in oxidative stress response due to its influence on the production of reactive oxygen species in cells.

Pathways

Proteins like Dexras1 influence both MAPK and nitric oxide signaling pathways. In the MAPK pathway Dexras1 interacts with proteins like Raf-1 and MEK helping modulate cellular responses to growth signals. Through nitric oxide signaling it plays a role in neuronal communication and vascular relaxation processes. These pathways highlight its importance in integrative functions that involve other Ras-related proteins and kinases contributing to complex signal transduction networks within the cell.

Research connects Dexras1 with neurological conditions and some forms of cancer. Altered expressions or mutations in Dexras1 may contribute to neurodegenerative diseases potentially through dysregulated neuronal signaling and oxidative stress pathways with related impacts on proteins like NMDA receptors. In cancer its pathways may influence proliferative and apoptotic processes revealing potential crosstalk with oncogenic Ras proteins which are implicated in various malignancies. These connections suggest that Dexras1 could serve as a potential target for therapeutic interventions in these disorders.