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AB123162

Recombinant Human DHRS9 protein

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Recombinant Human DHRS9 protein is a Human Full Length protein, in the 18 to 319 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

RDH15, SDR9C4, UNQ835/PRO1773, DHRS9, Dehydrogenase/reductase SDR family member 9, 3-alpha hydroxysteroid dehydrogenase, NADP-dependent retinol dehydrogenase/reductase, RDH-E2, RDHL, Retinol dehydrogenase 15, Short chain dehydrogenase/reductase family 9C member 4, Short-chain dehydrogenase/reductase retSDR8, Tracheobronchial epithelial cell-specific retinol dehydrogenase, 3-alpha-HSD, RDH-TBE

1 Images
SDS-PAGE - Recombinant Human DHRS9 protein (AB123162)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human DHRS9 protein (AB123162)

15% SDS PAGE analysis of 3 µg of Human DHRS9 protein (ab123162).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9BPW9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.02% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV","proteinLength":"Full Length","predictedMolecularWeight":"35.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":319,"aminoAcidStart":18,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BPW9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DHRS9 also known as dehydrogenase/reductase SDR family member 9 is an enzyme encoded by the DHRS9 gene. It belongs to the short-chain dehydrogenases/reductases (SDR) family and has a molecular mass of about 34 kDa. This protein acts mainly as an oxidoreductase involved in the metabolism of various substrates including retinoids and xenobiotics. DHRS9 has broad tissue distribution but high expression levels are noted in the liver kidney and placenta.
Biological function summary

As a member of the SDR family DHRS9 plays roles in redox reactions that are important for metabolic functions. It does not typically form complexes with other proteins but cooperates with enzymes such as retinol dehydrogenases. This protein is involved in the conversion of retinol to retinal which is a part of vitamin A metabolism that is essential for vision and cellular differentiation.

Pathways

Several significant metabolic processes involve DHRS9. It is primarily engaged in retinoic acid metabolism influencing retinoid signaling pathways which are vital for embryonic development and homeostasis. In these pathways DHRS9 interacts closely with retinoic acid receptors (RAR) and cellular retinoic acid-binding proteins which regulate gene expression required for cell differentiation and proliferation.

Research connects DHRS9 to specific conditions. Aberrant expression of DHRS9 has been associated with certain liver diseases and cancer types. In cases of liver disease misregulation of DHRS9 affects retinol metabolism impacting liver function and regenerative processes. Studies also suggest linkage between DHRS9 and RARs in oncogenic pathways where altered retinoic acid metabolism may affect tumor suppression mechanisms.
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Specifications

Form

Liquid

Additional notes

ab123162 was purified by using conventional chromatography.

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General info

Function

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed : 11294878, PubMed : 29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed : 11304534, PubMed : 12618084). Can utilize both NADH and NADPH.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Product protocols

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Target data

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed : 11294878, PubMed : 29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed : 11304534, PubMed : 12618084). Can utilize both NADH and NADPH.
See full target information DHRS9
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