Recombinant Human Dkk3 protein (denatured) is a Human Full Length protein, in the 22 to 350 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
< s t r o n g > M G S S H H H Y H H S S G L V P R G S H M G S M < / s t r o n g > A P A P T A T S A P V K P G P A L S Y P Q E E A T L N E M F R E V E E L M E D T Q H K L R S A V E E M E A E E A A A K A S S E V N L A N L P P S Y H N E T N T D T K V G N N T I H V H R E I H K I T N N Q T G Q M V F S E T V I T S V G D E E G R R S H E C I I D E D C G P S M Y C Q F A S F Q Y T C Q P C R G Q R M L C T R D S E C C G D Q L C V W G H C T K M A T R G S N G T I C D N Q R D C Q P G L C C A F Q R G L L F P V C T P L P V E G E L C H D P A S R L L D L I T W E L E P D G A L D R C P C A S G L L C Q P H S H S L V Y V C K P T F V G S R D Q D G E I L L P R E V P D E Y E V G S F M E E V R Q E L E D L E R S L T E E M A L R E P A A A A A A L L G G E E I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Alternative names
REIC, UNQ258/PRO295, DKK3, Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3
Recommended products
Recombinant Human Dkk3 protein (denatured) is a Human Full Length protein, in the 22 to 350 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q9UBP4-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 6.01% Urea, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- < s t r o n g > M G S S H H H Y H H S S G L V P R G S H M G S M < / s t r o n g > A P A P T A T S A P V K P G P A L S Y P Q E E A T L N E M F R E V E E L M E D T Q H K L R S A V E E M E A E E A A A K A S S E V N L A N L P P S Y H N E T N T D T K V G N N T I H V H R E I H K I T N N Q T G Q M V F S E T V I T S V G D E E G R R S H E C I I D E D C G P S M Y C Q F A S F Q Y T C Q P C R G Q R M L C T R D S E C C G D Q L C V W G H C T K M A T R G S N G T I C D N Q R D C Q P G L C C A F Q R G L L F P V C T P L P V E G E L C H D P A S R L L D L I T W E L E P D G A L D R C P C A S G L L C Q P H S H S L V Y V C K P T F V G S R D Q D G E I L L P R E V P D E Y E V G S F M E E V R Q E L E D L E R S L T E E M A L R E P A A A A A A L L G G E E I
- Accession
- Q9UBP4
- Protein length
- Full Length
- Predicted molecular weight
- 38.8 kDa
- Amino acids
- 22 to 350
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
- Sequence similarities
Belongs to the dickkopf family.
- Post-translational modifications
N- and O-glycosylated.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human Dkk3 protein (denatured) (ab131700)
15% SDS-PAGE showing ab131700 at approximately 38.8kDa (3µg).
Downloads
Product protocols
- Visit the general protocols
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