Recombinant Human DLK-1 protein (Fc Chimera) is a Human Full Length protein, in the 1 to 303 aa range, expressed in HEK 293, with >90% purity, < 0.01 EU/µg endotoxin level and suitable for SDS-PAGE.
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May have a role in neuroendocrine differentiation.
DLK, DLK1, Protein delta homolog 1, DLK-1, pG2
Recombinant Human DLK-1 protein (Fc Chimera) is a Human Full Length protein, in the 1 to 303 aa range, expressed in HEK 293, with >90% purity, < 0.01 EU/µg endotoxin level and suitable for SDS-PAGE.
Constituents: 99% PBS, 0.02% 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
May have a role in neuroendocrine differentiation.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Delta-like 1 homolog (DLK-1) also known as Pref-1 (preadipocyte factor 1) is a protein involved in a wide range of cellular processes. The mass of DLK-1 is approximately 65 kDa. This protein is expressed in various tissues including the liver brain and endocrine glands. DLK-1 has an important role in the regulation of cell differentiation and growth acting as a signal molecule that influences tissue development and regeneration.
DLK-1 serves a function in the inhibition of adipocyte differentiation and the maintenance of preadipocyte phenotype. It does not form part of a complex but interacts with membrane-bound receptors to mediate signaling pathways that impact tissue development. Researchers study its role in embryonic development and its downregulation is a significant factor during the differentiation of mesenchymal cells. Due to these interactions DLK-1 has a pivotal involvement in processes governing tissue regeneration and growth control.
Better understanding of DLK-1 involves examining its interaction in the Notch signaling pathway. This important pathway related to cell fate decisions features pathways with other proteins like Notch-1 and Notch-3. The relationship helps modulate the fate and proliferation of cells. DLK-1 also has associations with pathways involving phosphoinositide 3-kinase (PI3K) which influences cell growth and survival through related proteins such as AKT.
DLK-1 has shown associations with cancer and metabolic disorders. Overexpression of DLK-1 is linked to obesity due to its impact on preadipocyte differentiation. Additionally higher levels of DLK-1 can correlate with certain cancer progression where it acts alongside proteins like Notch-1 in promoting tumor cell growth. Understanding DLK-1's role in these contexts highlights the importance of DLK-1 as both a diagnostic marker and potential therapeutic target.
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