Recombinant Human DLK-2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DLK-2 also known as Delta-like 2 homolog is a protein characterized by a molecular mass of approximately 29 kDa. It functions as a modulator within cells interacting with various cellular signaling processes. The protein is expressed in numerous tissues including the brain and muscle tissues playing a role in cellular communication. As part of the Notch signaling pathway DLK-2 influences cell differentiation growth and apoptosis by interacting with other molecular components.

Biological function summary

DLK-2 has a critical role in regulating processes like neurogenesis and tissue development. It does not act as part of a complex but instead modulates cellular environments by binding with other signaling molecules. It functions by impacting cellular mechanisms such as cell fate decisions and maintaining homeostasis. DLK-2 is involved in transmitting signals that influence whether a cell will differentiate into a specific cell type or remain undifferentiated.

Pathways

DLK-2 significantly impacts the Notch signaling pathway and additionally interacts with the Wnt signaling pathway. Its relation to Notch signaling involves collaboration with proteins such as Notch receptors and ligands facilitating communication across the cell membrane. In the Wnt pathway DLK-2 acts indirectly by modifying the intensity of the signaling cascade which provides additional layers of regulation important to cellular processes like proliferation and differentiation.

DLK-2 associates with conditions such as cancer and neurodegenerative diseases. Research indicates that abnormal expression of DLK-2 may contribute to tumorigenesis due to its role in cell growth regulation. Additionally its modulation of neuronal development processes ties it to neurodegenerative disorders where imbalance in signaling pathways affects neuronal survival. It connects to proteins like Notch1 and beta-catenin which are involved in these pathological states suggesting that DLK-2 might serve as a potential target for therapeutic strategies in these conditions.