Recombinant Human DLK-2 protein is a Human Fragment protein, in the 1 to 306 aa range, expressed in HEK 293, with >90% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
EGFL9, UNQ2903/PRO28633, DLK2, Protein delta homolog 2, DLK-2, Epidermal growth factor-like protein 9, EGF-like protein 9
Recombinant Human DLK-2 protein is a Human Fragment protein, in the 1 to 306 aa range, expressed in HEK 293, with >90% purity, < 0.1 EU/µg endotoxin level and suitable for SDS-PAGE.
Constituents: PBS
ab109347 is an 0.2 µm filtered solution.
Regulates adipogenesis.
DLK-2 also known as Delta-like 2 homolog is a protein characterized by a molecular mass of approximately 29 kDa. It functions as a modulator within cells interacting with various cellular signaling processes. The protein is expressed in numerous tissues including the brain and muscle tissues playing a role in cellular communication. As part of the Notch signaling pathway DLK-2 influences cell differentiation growth and apoptosis by interacting with other molecular components.
DLK-2 has a critical role in regulating processes like neurogenesis and tissue development. It does not act as part of a complex but instead modulates cellular environments by binding with other signaling molecules. It functions by impacting cellular mechanisms such as cell fate decisions and maintaining homeostasis. DLK-2 is involved in transmitting signals that influence whether a cell will differentiate into a specific cell type or remain undifferentiated.
DLK-2 significantly impacts the Notch signaling pathway and additionally interacts with the Wnt signaling pathway. Its relation to Notch signaling involves collaboration with proteins such as Notch receptors and ligands facilitating communication across the cell membrane. In the Wnt pathway DLK-2 acts indirectly by modifying the intensity of the signaling cascade which provides additional layers of regulation important to cellular processes like proliferation and differentiation.
DLK-2 associates with conditions such as cancer and neurodegenerative diseases. Research indicates that abnormal expression of DLK-2 may contribute to tumorigenesis due to its role in cell growth regulation. Additionally its modulation of neuronal development processes ties it to neurodegenerative disorders where imbalance in signaling pathways affects neuronal survival. It connects to proteins like Notch1 and beta-catenin which are involved in these pathological states suggesting that DLK-2 might serve as a potential target for therapeutic strategies in these conditions.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com