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AB276592

Recombinant Human DPEP2 protein (His tag)

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Recombinant Human DPEP2 protein (His tag) is a Human Fragment protein, in the 1 to 376 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

UNQ284/PRO323, DPEP2, Dipeptidase 2

1 Images
SDS-PAGE - Recombinant Human DPEP2 protein (His tag) (AB276592)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human DPEP2 protein (His tag) (AB276592)

SDS-PAGE analysis of ab276592.

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9H4A9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQKLACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLTDFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDILQLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVS","proteinLength":"Fragment","predictedMolecularWeight":"53 kDa","actualMolecularWeight":null,"aminoAcidEnd":376,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H4A9","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dipeptidase 2 (DPEP2) also known as renal dipeptidase 2 is an enzyme that catalyzes the hydrolysis of dipeptides and demonstrates a strong preference for cysteinyl glycine substrates. It has a molecular mass of approximately 49 kDa. DPEP2 is expressed in a variety of tissues but shows significant levels in the kidney and intestines. This distribution suggests a role in peptide metabolism particularly in the renal system where dipeptidase activity is high.
Biological function summary

The enzyme participates in the metabolism of glutathione and leukotrienes among others. DPEP2 is not a part of a larger complex; it functions independently to perform its enzymatic activities. Its role in leukotriene metabolism suggests an involvement in inflammatory response mechanisms which can further impact vascular functions and tissue repair processes.

Pathways

DPEP2 is an important player within the leukotriene degradation and glutathione metabolism pathways. It influences the catalysis of leukotrienes into inactive forms thereby helping regulate inflammatory responses. DPEP2 works closely with related proteins like DPEP1 which shares functional similarities and can act in the same pathways highlighting its significance in maintaining cellular homeostasis.

Altered expression or activity of DPEP2 has been associated with conditions like asthma and renal tubular acidosis. In asthma the improper regulation of leukotriene degradation due to impaired DPEP2 function can contribute to excess inflammation and bronchoconstriction. DPEP2 interacts with leukotriene-switching enzymes anchoring its connection to the disease mechanism.
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General info

Function

Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed : 32325220). Hydrolyzes cystinyl-bis-glycine (PubMed : 32325220).. Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway.

Sequence similarities

Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.

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Product protocols

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Target data

Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed : 32325220). Hydrolyzes cystinyl-bis-glycine (PubMed : 32325220).. Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway.
See full target information DPEP2
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