Recombinant Human DPH3P1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DPH3P1 also known as diphthamide biosynthesis 3 protein homolog pseudogene 1 is a protein-related entity with a molecular mass approximating 12 kDa. This factor is expressed in various tissues with notable presence in the cytoplasm and possibly within the nucleus of human cells. Mechanically DPH3P1 is associated with cellular responses influencing protein synthesis by grazing the diphthamide biosynthesis pathway. Though named as a pseudogene DPH3P1 displays activity in regulating certain gene expressions pointing to its functional relevance.

Biological function summary

DPH3P1 contributes to the cellular machinery by aiding in diphthamide modification a unique post-translational modification of histidine residues within eukaryotic elongation factor 2 (eEF-2). It participates as a component of a complex involved in processing proteins essential for cellular functions. Through its mechanical actions DPH3P1 helps maintain proper protein synthesis balance which is critical for cell growth and division. The interaction of DPH3P1 with other proteins in this complex signposts critical roles in cellular homeostasis.

Pathways

DPH3P1 plays a part in the diphthamide biosynthesis pathway and the broader protein synthesis processes. This protein harmonizes its role with eukaryotic elongation factor 2 (eEF-2) a primary binding partner maintaining the fidelity and efficiency of translation elongation. Moreover the presence of DPH3P1 in the protein synthesis system connects it to cellular stress response pathways where it may influence cell survival and adaptation under stress conditions. These connections highlight its significant role in these essential pathways.

DPH3P1 exhibits a link to health issues like cancer and neurodevelopmental disorders. Mutations or dysfunctions in the diphthamide pathway can disrupt protein synthesis possibly leading to oncogenic transformations or developmental issues in nerve cells. During pathological conditions involvement of proteins like eEF-2 and others within the diphthamide pathway can be observed which indicates significant interplay with DPH3P1. These associations could guide targeted research for therapeutic interventions aiming at these diseases and their underlying molecular mechanisms.