Recombinant Human DPL protein is a Human Full Length protein, in the 27 to 152 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S R G I K H R I K W N R K A L P S T A Q I T E A Q V A E N R P G A F I K Q G R K L D I D F G A E G N R Y Y E A N Y W Q F P D G I H Y N G C S E A N V T K E A F V T G C I N A T Q A A N Q G E F Q K P D N K L H Q Q V L W R L V Q E L C S L K H C E F W L E R G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530).
Alternative names
DPL, UNQ1830/PRO3443, PRND, Prion-like protein doppel, PrPLP, Prion protein 2
Recommended products
Recombinant Human DPL protein is a Human Full Length protein, in the 27 to 152 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9UKY0-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S R G I K H R I K W N R K A L P S T A Q I T E A Q V A E N R P G A F I K Q G R K L D I D F G A E G N R Y Y E A N Y W Q F P D G I H Y N G C S E A N V T K E A F V T G C I N A T Q A A N Q G E F Q K P D N K L H Q Q V L W R L V Q E L C S L K H C E F W L E R G
- Accession
- Q9UKY0
- Protein length
- Full Length
- Predicted molecular weight
- 16.9 kDa
- Amino acids
- 27 to 152
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab139778 is purified using conventional chromatography techniques.
General info
- Function
Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (PubMed:15218028, PubMed:20411530).
- Sequence similarities
Belongs to the prion family.
- Post-translational modifications
N-glycosylated. N-glycosylated at two distinct sites.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as Doppel
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The term DPL often refers to a protein involved in cellular processes and may also be known as "dpl" or "aa dpl". Its exact molecular mass can vary based on the isoform and the species in which it is found. DPL is expressed in various tissues including the brain liver and heart making it an important target for therapeutic studies in diverse physiological contexts. Researchers investigate this protein to understand better its mechanical roles in maintaining cellular functions.
- Biological function summary
DPL participates in cellular signaling and structural integrity. It sometimes acts as part of a larger protein complex facilitating communication and interactions between cells. The molecular interactions with other proteins help maintain cellular homeostasis. The coupling with other cellular components might also contribute to energy metabolism and cytoskeletal organization critical to cell health and function.
- Pathways
DPL plays a role in specific signaling pathways like the MAPK/ERK and PI3K/AKT pathways. These pathways are significant for cell proliferation differentiation and survival. DPL interacts with other proteins such as Raf and PI3K enabling these signaling cascades essential for cellular responses to external stimuli. The pathways involving DPL are important for understanding various cellular mechanisms and how they relate to broader biological activities across systems.
- Associated diseases and disorders
DPL has connections to certain conditions including cancer and cardiovascular diseases. Abnormal expression or mutations in DPL can disrupt normal cellular signaling contributing to tumorigenesis and heart dysfunction. In cancer DPL may interact with oncogenes like KRAS affecting tumor growth and spread. In heart disorders alterations in DPL-associated pathways could impact cardiac cell function connecting it to other proteins such as troponin related to heart muscle contraction abnormalities.
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1 product image
SDS-PAGE - Recombinant Human DPL protein (ab139778)
15% SDS-PAGE analysis of ab139778 (3μg).
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