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Recombinant human DPP4 protein is a Human Full Length protein, in the 39 to 766 aa range, expressed in Baculovirus infected BTI-TN-5B1-4, with >95% purity and suitable for WB, SDS-PAGE.
Alternative names=Dipeptidyl peptidase 4, ADABP, Adenosine deaminase complexing protein 2, Dipeptidyl peptidase IV, T-cell activation antigen CD26, TP103, ADCP-2, DPP IV, DPP4, ADCP2, CD26
- Purity
>95% SDS-PAGE
- Expression system
Baculovirus infected BTI-TN-5B1-4 cells
- Tags
His tag C-Terminus
- Applications
WB, SDS-PAGE
- Biologically active
Yes
- Sequence
S R K T Y T L T D Y L K N T Y R L K L Y S L R W I S D H E Y L Y K Q E N N I L V F N A E Y G N S S V F L E N S T F D E F G H S I N D Y S I S P D G Q F I L L E Y N Y V K Q W R H S Y T A S Y D I Y D L N K R Q L I T E E R I P N N T Q W V T W S P V G H K L A Y V W N N D I Y V K I E P N L P S Y R I T W T G K E D I I Y N G I T D W V Y E E E V F S A Y S A L W W S P N G T F L A Y A Q F N D T E V P L I E Y S F Y S D E S L Q Y P K T V R V P Y P K A G A V N P T V K F F V V N T D S L S S V T N A T S I Q I T A P A S M L I G D H Y L C D V T W A T Q E R I S L Q W L R R I Q N Y S V M D I C D Y D E S S G R W N C L V A R Q H I E M S T T G W V G R F R P S E P H F T L D G N S F Y K I I S N E E G Y R H I C Y F Q I D K K D C T F I T K G T W E V I G I E A L T S D Y L Y Y I S N E Y K G M P G G R N L Y K I Q L S D Y T K V T C L S C E L N P E R C Q Y Y S V S F S K E A K Y Y Q L R C S G P G L P L Y T L H S S V N D K G L R V L E D N S A L D K M L Q N V Q M P S K K L D F I I L N E T K F W Y Q M I L P P H F D K S K K Y P L L L D V Y A G P C S Q K A D T V F R L N W A T Y L A S T E N I I V A S F D G R G S G Y Q G D K I M H A I N R R L G T F E V E D Q I E A A R Q F S K M G F V D N K R I A I W G W S Y G G Y V T S M V L G S G S G V F K C G I A V A P V S R W E Y Y D S V Y T E R Y M G L P T P E D N L D H Y R N S T V M S R A E N F K Q V E Y L L I H G T A D D N V H F Q Q S A Q I S K A L V D V G V D F Q A M W Y T D E D H G I A S S T A H Q H I Y T H M S H F I K Q C F S L P S G R L V P R G S H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application WB | Reactivity Reacts | Dilution info - | Notes Ab79138 can be used as a WB positive control in conjunction with ab86806. |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes On SDS-PAGE under denatured condition, apparent molecular weight of glycosylated CD26 protein will be approximately 90kDa. |
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Recombinant human DPP4 protein is a Human Full Length protein, in the 39 to 766 aa range, expressed in Baculovirus infected BTI-TN-5B1-4, with >95% purity and suitable for WB, SDS-PAGE.
Alternative names=Dipeptidyl peptidase 4, ADABP, Adenosine deaminase complexing protein 2, Dipeptidyl peptidase IV, T-cell activation antigen CD26, TP103, ADCP-2, DPP IV, DPP4, ADCP2, CD26
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Baculovirus infected BTI-TN-5B1-4 cells
- Tags
His tag C-Terminus
- Applications
WB, SDS-PAGE
- Biologically active
Yes
- Biological activity
Specific activity is > 200unit/mg, One unit produces 1.0 umole of p-Nitroaniline from Gly-Pro- p-Nitroaniline per minute at pH 8.0 at 37°C.
- Amino acids
39 to 766
- Sequence
S R K T Y T L T D Y L K N T Y R L K L Y S L R W I S D H E Y L Y K Q E N N I L V F N A E Y G N S S V F L E N S T F D E F G H S I N D Y S I S P D G Q F I L L E Y N Y V K Q W R H S Y T A S Y D I Y D L N K R Q L I T E E R I P N N T Q W V T W S P V G H K L A Y V W N N D I Y V K I E P N L P S Y R I T W T G K E D I I Y N G I T D W V Y E E E V F S A Y S A L W W S P N G T F L A Y A Q F N D T E V P L I E Y S F Y S D E S L Q Y P K T V R V P Y P K A G A V N P T V K F F V V N T D S L S S V T N A T S I Q I T A P A S M L I G D H Y L C D V T W A T Q E R I S L Q W L R R I Q N Y S V M D I C D Y D E S S G R W N C L V A R Q H I E M S T T G W V G R F R P S E P H F T L D G N S F Y K I I S N E E G Y R H I C Y F Q I D K K D C T F I T K G T W E V I G I E A L T S D Y L Y Y I S N E Y K G M P G G R N L Y K I Q L S D Y T K V T C L S C E L N P E R C Q Y Y S V S F S K E A K Y Y Q L R C S G P G L P L Y T L H S S V N D K G L R V L E D N S A L D K M L Q N V Q M P S K K L D F I I L N E T K F W Y Q M I L P P H F D K S K K Y P L L L D V Y A G P C S Q K A D T V F R L N W A T Y L A S T E N I I V A S F D G R G S G Y Q G D K I M H A I N R R L G T F E V E D Q I E A A R Q F S K M G F V D N K R I A I W G W S Y G G Y V T S M V L G S G S G V F K C G I A V A P V S R W E Y Y D S V Y T E R Y M G L P T P E D N L D H Y R N S T V M S R A E N F K Q V E Y L L I H G T A D D N V H F Q Q S A Q I S K A L V D V G V D F Q A M W Y T D E D H G I A S S T A H Q H I Y T H M S H F I K Q C F S L P S G R L V P R G S H H H H H H
- Accession
- P27487-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0292% EDTA
Specifications
- Form
Liquid
- Additional notes
Affinity purified
General info
- Function
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948).
- Sequence similarities
Belongs to the peptidase S9B family. DPPIV subfamily.
- Post-translational modifications
The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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