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AB151363

Recombinant Human DR6 protein

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Recombinant Human DR6 protein is a Human Fragment protein, in the 42 to 350 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

CD358, DR6, UNQ437/PRO868, TNFRSF21, Tumor necrosis factor receptor superfamily member 21, Death receptor 6

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

O75509

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in PBS

Storage buffer

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"QPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"34.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":350,"aminoAcidStart":42,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O75509","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

DR6 also known as Death Receptor 6 or TNFRSF21 is a member of the tumor necrosis factor receptor superfamily. This protein has a mass of approximately 71 kDa and is expressed in a variety of tissues including the heart lymph nodes and spleen. DR6 functions as a transmembrane receptor and plays a critical role in mediating apoptosis and cellular communication.
Biological function summary

DR6 acts as a mediator in cell death signaling pathways. It associates with other proteins to form a death-inducing signaling complex triggering apoptotic pathways upon activation by specific ligands. DR6 is involved in regulating cell growth differentiation and survival. It also plays a role in modulating the immune response especially the adaptive immune response by influencing T-cell activation and proliferation.

Pathways

DR6 is involved in apoptosis and immune signaling pathways. It interacts with proteins such as caspases and adaptor proteins in the apoptotic pathways. In the immune system DR6 is related to proteins like TRAF family members which help in transmitting signals required for T-cell responses. DR6 influences several downstream effects that are critical for maintaining cellular homeostasis and immune regulation.

DR6 has been implicated in neurodegenerative diseases and cancer. Altered expression or function of DR6 can contribute to diseases such as Alzheimer's disease by promoting neuronal apoptosis. In cancer aberrant DR6 signaling may affect tumor cell survival and progression. DR6's interaction with amyloid precursor protein (APP) in neurodegenerative diseases and its association with certain tumor necrosis factor ligands in cancer highlight its significance in disease pathways.
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Specifications

Form

Lyophilized

Additional notes

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis : recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed : 34012073).

Post-translational modifications

Oxidized in response to reactive oxygen species (ROS), leading to endocytosis.

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Product protocols

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Target data

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis : recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed : 34012073).
See full target information TNFRSF21
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Complementary Products

Primary Antibodies

AB8417

Anti-DR6 antibody

Western blot - Anti-DR6 antibody (AB8417)

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Cell Lines & Lysates

AB94106

DR6 overexpression 293T lysate (whole cell)

Western blot - DR6 overexpression 293T lysate (whole cell) (AB94106)

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Primary Antibodies

AB233558

Anti-NCR1/NKp46 antibody [EPR23097-35]

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Multiplex immunohistochemistry - Anti-NCR1/NKp46 antibody [EPR23097-35] (AB233558)

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Primary Antibodies

AB16669

Anti-CD3 epsilon antibody [SP7]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD3 epsilon antibody [SP7] (AB16669)

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