Recombinant Human DRG1 protein (His tag N-Terminus)
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Recombinant Human DRG1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
NEDD3, DRG1, Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, Translation factor GTPase DRG1, NEDD-3, TRAFAC GTPase DRG1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human DRG1 protein (His tag N-Terminus) (AB109940)
15% SDS-PAGE analysis of 3μg ab109940.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DRG1 engages in several critical cellular processes beyond its mechanical functions. One of its notable roles involves contributions to ribosome biogenesis although it does not form a permanent complex with the ribosome. The protein supports cellular growth and division highlighting its potential in affecting cell cycle regulation. DRG1 associates transiently with other proteins allowing it to influence a range of biological functions including cellular growth signaling pathways.
Pathways
Research indicates that DRG1 links to important regulatory networks such as the Ras signaling and translational control pathways. Within these pathways DRG1 interacts with proteins like eukaryotic initiation factors which are important for translation regulation. This interaction plays a role in coordinating protein synthesis which supports overall cellular growth and response to environmental cues. Understanding its place in these pathways sheds light on how cells control protein production and growth.
Specifications
Form
Liquid
Additional notes
ab109940 was purified using conventional chromatography techniques.
General info
Function
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed : 23711155, PubMed : 29915238, PubMed : 37179472). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed : 23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed : 19819225, PubMed : 29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed : 28855639).
Sequence similarities
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Post-translational modifications
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.. Phosphorylated at Thr-100 by STK16.. Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.. Polyubiquitinated; this modification induces proteolytic degradation and is impaired by interaction with ZC3H15.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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