Recombinant Human DS-1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

DS-1 contributes to the assembly and stability of multi-protein complexes that control synaptic transmission. It interacts with neurotransmitter receptors at the synaptic membrane where it influences receptor clustering and signaling fidelity. This interaction is critical for maintaining synaptic strength and ensuring proper neural communication. Studies indicate that DS-1 works together with other synaptic proteins forming complexes that affect synapse formation and remodeling.

Pathways

DS-1 integrates into significant signaling pathways that regulate neuronal excitability and synaptic plasticity such as the MAPK/ERK cascade. It associates with proteins like Ras and RAF mediating signal relay from cell surface receptors to nuclear targets that orchestrate cellular growth and differentiation. This interaction highlights the importance of DS-1 in the modulation of synaptic plasticity linking extracellular signals to changes in gene expression necessary for long-term potentiation and memory storage.