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AB163552

Recombinant Human DSCAML1 protein (GST tag N-Terminus)

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Recombinant Human DSCAML1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1922 to 2008 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

DSCAM2, KIAA1132, DSCAML1, Cell adhesion molecule DSCAML1, Down syndrome cell adhesion molecule 2, Down syndrome cell adhesion molecule-like protein 1

1 Images
SDS-PAGE - Recombinant Human DSCAML1 protein (GST tag N-Terminus) (AB163552)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human DSCAML1 protein (GST tag N-Terminus) (AB163552)

ab163552 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q8TD84

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"SEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAFFRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDP","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":2008,"aminoAcidStart":1922,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TD84","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein DSCAML1 also known as Down syndrome cell adhesion molecule-like 1 plays a mechanical role in cell adhesion and signaling. This protein with a mass of approximately 220 kDa belongs to the immunoglobulin superfamily. DSCAML1 is expressed in various tissues most notably in the nervous system where it helps in the development of neural circuits. The target is known for its complex structure which allows it to mediate homophilic cell-cell interactions essential for neuronal positioning and axonal pathfinding.
Biological function summary

DSCAML1 is involved in neural patterning and synaptic connectivity. The protein contributes to neural migration processes during development ensuring proper brain morphogenesis. Research suggests that DSCAML1 forms part of a molecular complex that aids in axon guidance important for network formation within the brain. Together with other cell adhesion molecules DSCAML1 influences synapse formation and stability impacting neural networks' functional integrity.

Pathways

DSCAML1 participates in signaling pathways critical for nervous system development. It significantly influences axon guidance and synaptic signaling pathways. DSCAML1 interacts with other proteins like DSCAM and DCC (Deleted in Colorectal Cancer) which are known to play roles in cellular communication and neuronal growth processes. These interactions contribute to the proteins' collective ability to orchestrate developmental and functional aspects of the central nervous system.

DSCAML1 mutations have associations with neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. Alterations in DSCAML1 functions may disrupt neural circuitry leading to these conditions. Proteins like DSCAM whose gene duplication or mutations often occur in Down syndrome share pathways or functions with DSCAML1 and disruptions in these interactions stand linked to altered neural development and related cognitive concerns.
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Specifications

Form

Liquid

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General info

Function

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed : 11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina : expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

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Product protocols

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Target data

Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed : 11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina : expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
See full target information DSCAML1
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