Recombinant Human DSU protein (His tag)
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Recombinant Human DSU protein (His tag) is a Human Full Length protein, in the 1 to 214 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
DSU, HDCGA21P, MREG, Melanoregulin, Dilute suppressor protein homolog
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human DSU protein (His tag) (AB177607)
15% SDS-PAGE analysis of ab177607 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The conversion of sulfur-containing compounds by DSU supports important cellular functions such as detoxification and biotransformation. DSU becomes active as part of a larger enzymatic complex that includes accessory proteins. This complex satisfies cellular requirements for sulfur enabling proper cellular respiration and energy metabolism. It is also pertinent in the synthesis of vital sulfur-containing biomolecules.
Pathways
DSU participates in the transsulfuration pathway which is an essential component of the sulfur amino acid metabolism. This pathway links methionine and cysteine metabolism assisting in maintaining balance within cells. DSU works closely with enzymes like cystathionine gamma-lyase which facilitates further modifications of the sulfur-containing substrates. The interplay between these proteins ensures seamless transitions in the sulfur metabolic pathways.
Specifications
Form
Liquid
Additional notes
ab177607 was purified using conventional chromatography techniques.
General info
Function
Probably functions as a cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate, but not phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 4,5-bisphosphate (By similarity). Required for normal phagosome clearing and normal activation of lysosomal enzymes in lysosomes from retinal pigment epithelium cells (PubMed : 19240024). Required for normal degradation of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2E) in the eye. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).
Sequence similarities
Belongs to the melanoregulin family.
Post-translational modifications
Palmitoylated. Palmitoylation is required to maintain the protein at the melanosome membrane.
Subcellular localisation
Lysosome membrane
Target data
Complementary Products
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