Recombinant Human Dub3 protein (GST tag N-Terminus)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human Dub3 protein (GST tag N-Terminus) is a Human Fragment protein, in the 431 to 530 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
View Alternative Names
DUB3, USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M, USP17L2, Ubiquitin carboxyl-terminal hydrolase 17, Deubiquitinating enzyme 17-like protein 2, Deubiquitinating protein 3, Ubiquitin carboxyl-terminal hydrolase 17-like protein 2, Ubiquitin thioesterase 17-like protein 2, Ubiquitin-specific-processing protease 17-like protein 2, DUB-3
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Dub3 protein (GST tag N-Terminus) (AB112436)
12.5% SDS-PAGE showing ab112436 at approximately 36.63kDa stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Deubiquitinase 3 plays a significant role in regulating cell cycle progression and DNA damage response. It is often found within a larger complex where it interacts with other proteins to exert its function. This enzyme modulates the activity of several key proteins such as Cyclin A and Cdc25A by controlling their ubiquitination status which influences cell division and repair mechanisms in the cell. By maintaining these processes Dub3 ensures the fidelity of the cell cycle and genomic integrity.
Pathways
The function of Dub3 integrates into the ubiquitin-proteasome system and the DNA damage repair pathway. In the ubiquitin-proteasome system Dub3 removes ubiquitin chains from target proteins which determines their fate either for degradation or stabilization. On the DNA damage repair front Dub3 contributes to pathways involving proteins like p53 by deubiquitinating and stabilizing them allowing for an adequate response to DNA damage signals and maintaining cellular homeostasis.
Specifications
Form
Liquid
General info
Function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection.
Sequence similarities
Belongs to the peptidase C19 family. USP17 subfamily.
Subcellular localisation
Nucleus
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com