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AB180296

Recombinant Human DUSP22 protein (denatured) (His tag N-Terminus)

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Recombinant Human DUSP22 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 184 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

JSP1, LMWDSP2, MKPX, DUSP22, Dual specificity protein phosphatase 22, JNK pathway associated phosphatase, JNK-stimulatory phosphatase-1, Low molecular weight dual specificity phosphatase 2, Mitogen-activated protein kinase phosphatase x, JKAP, JSP-1, LMW-DSP2, MAP kinase phosphatase x, MKP-x

1 Images
SDS-PAGE - Recombinant Human DUSP22 protein (denatured) (His tag N-Terminus) (AB180296)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human DUSP22 protein (denatured) (His tag N-Terminus) (AB180296)

15% SDS-PAGE analysis of ab180296 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NRW4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAFLRRL","proteinLength":"Full Length","predictedMolecularWeight":"23.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":184,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NRW4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed : 24714587, PubMed : 38225265). Activates the JNK signaling pathway (PubMed : 11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed : 24714587, PubMed : 38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed : 38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed : 24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed : 38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity).

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Post-translational modifications

Myristoylation regulates subcellular location, and is necessary for activation of JNK.

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Product protocols

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Target data

Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed : 24714587, PubMed : 38225265). Activates the JNK signaling pathway (PubMed : 11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed : 24714587, PubMed : 38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed : 38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed : 24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed : 38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity).
See full target information DUSP22
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