JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB183239

Recombinant Human DUSP6 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human DUSP6 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 381 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MKP3, PYST1, DUSP6, Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3

1 Images
Western blot - Recombinant Human DUSP6 protein (His tag N-Terminus) (AB183239)
  • WB

Supplier Data

Western blot - Recombinant Human DUSP6 protein (His tag N-Terminus) (AB183239)

15% SDS-PAGE analysis of ab183239 (3 μg)

All lanes:

Western blot - Recombinant Human DUSP6 protein (His tag N-Terminus) (ab183239)

false

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q16828

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST","proteinLength":"Full Length","predictedMolecularWeight":"44 kDa","actualMolecularWeight":null,"aminoAcidEnd":381,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16828","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column
style
left-column

Specifications

Form

Liquid

Additional notes

ab183239 was purified using conventional chromatography.

style
left-column

General info

Function

Inactivates MAP kinases. Has a specificity for the ERK family (PubMed : 9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed : 29043977).

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

style
left-column

Product protocols

style
left-column

Target data

Inactivates MAP kinases. Has a specificity for the ERK family (PubMed : 9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed : 29043977).
See full target information DUSP6
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:2503 PubMed38509064

2024

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ashenafi Bulle,Peng Liu,Kuljeet Seehra,Sapana Bansod,Yali Chen,Kiran Zahra,Vikas Somani,Iftikhar Ali Khawar,Hung-Po Chen,Paarth B Dodhiawala,Lin Li,Yutong Geng,Chia-Kuei Mo,Jay Mahsl,Li Ding,Ramaswamy Govindan,Sherri Davies,Jacqueline Mudd,William G Hawkins,Ryan C Fields,David G DeNardo,Deborah Knoerzer,Jason M Held,Patrick M Grierson,Andrea Wang-Gillam,Marianna B Ruzinova,Kian-Huat Lim
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB76310

Anti-DUSP6 antibody [EPR129Y]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-DUSP6 antibody [EPR129Y] (AB76310)

  • 5
  • 16
Primary Antibodies

AB195045

Anti-PAX6 antibody [EPR15858]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAX6 antibody [EPR15858] (AB195045)

  • 5
  • 9
Proteins & Peptides

AB61135

Recombinant human SHP1 protein

Functional Studies - Recombinant human SHP1 protein (AB61135)

  • 0
  • 0
Primary Antibodies

AB111947

Anti-GST antibody [EPR4236]

RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GST antibody [EPR4236] (AB111947)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com