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Recombinant Human DUSP6 protein is a Human Full Length protein, in the 1 to 381 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Alternative names=Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, MKP3, DUSP6, PYST1
- Purity
>85% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Sequence
M G S S H H H H H H S S G L V P R G S H M I D T L R P V P F A S E M A I S K T V A W L N E Q L E L G N E R L L L M D C R P Q E L Y E S S H I E S A I N V A I P G I M L R R L Q K G N
L P V R A L F T R G E D R D R F T R R C G T D T V V L Y D E S S S D W N E N T G G E S V L G L L L K K L K D E G C R A F Y L E G G F S K F Q A E F S L H C E T N L D G S C S S S S P
P L P V L G L G G L R I S S D S S S D I E S D L D R D P N S A T D S D G S P L S N S Q P S F P V E I L P F L Y L G C A K D S T N L D V L E E F G I K Y I L N V T P N L P N L F E N A
G E F K Y K Q I P I S D H W S Q N L S Q F F P E A I S F I D E A R G K N C G V L V H C L A G I S R S V T V T V A Y L M Q K L N L S M N D A Y D I V K M K K S N I S P N F N F M G Q L
L D F E R T L G L S S P C D N R V P A Q Q L Y F T T P S N Q N V Y Q V D S L Q S T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
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Recombinant Human DUSP6 protein is a Human Full Length protein, in the 1 to 381 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Alternative names=Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, MKP3, DUSP6, PYST1
Key facts
- Purity
>85% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Predicted molecular weight
44 kDa
- Amino acids
1 to 381
- Sequence
M G S S H H H H H H S S G L V P R G S H M I D T L R P V P F A S E M A I S K T V A W L N E Q L E L G N E R L L L M D C R P Q E L Y E S S H I E S A I N V A I P G I M L R R L Q K G N
L P V R A L F T R G E D R D R F T R R C G T D T V V L Y D E S S S D W N E N T G G E S V L G L L L K K L K D E G C R A F Y L E G G F S K F Q A E F S L H C E T N L D G S C S S S S P
P L P V L G L G G L R I S S D S S S D I E S D L D R D P N S A T D S D G S P L S N S Q P S F P V E I L P F L Y L G C A K D S T N L D V L E E F G I K Y I L N V T P N L P N L F E N A
G E F K Y K Q I P I S D H W S Q N L S Q F F P E A I S F I D E A R G K N C G V L V H C L A G I S R S V T V T V A Y L M Q K L N L S M N D A Y D I V K M K K S N I S P N F N F M G Q L
L D F E R T L G L S S P C D N R V P A Q Q L Y F T T P S N Q N V Y Q V D S L Q S T- Accession
- Q16828-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Specifications
- Form
Liquid
- Additional notes
ab183239 was purified using conventional chromatography.
General info
- Function
Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977).
- Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Product promise
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