Recombinant human Dystrophia myotonica protein kinase / DMPK
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Recombinant human Dystrophia myotonica protein kinase / DMPK is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with >80%, suitable for SDS-PAGE, WB, FuncS.
View Alternative Names
DM1PK, MDPK, Myotonin-protein kinase, MT-PK, DM-kinase, DM1 protein kinase, DMPK, Myotonic dystrophy protein kinase, DMK
- FuncS
Unknown
Functional Studies - Recombinant human Dystrophia myotonica protein kinase / DMPK (AB85755)
The specific activity of ab85755 was determined to be 4.5 nmol/min/mg.
- FuncS
Unknown
Functional Studies - Recombinant human Dystrophia myotonica protein kinase / DMPK (AB85755)
The specific activity of Dystrophia myotonica protein kinase / DMPK (ab85755) was determined to be 5.2 nmol/min/mg as per activity assay protocol
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human Dystrophia myotonica protein kinase / DMPK (AB85755)
SDS-PAGE showing ab85755 at approximately 105kDa.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human Dystrophia myotonica protein kinase / DMPK (AB85755)
SDS PAGE analysis of ab85755
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DMPK acts to regulate muscle function and integrity by modulating phosphorylation states within cells. It is not typically part of known multi-protein complexes but works alongside other kinases to affect signaling pathways. For example DMPK can influence actin filaments and myosin phosphorylation contributing to muscle cell contractility and stability. This regulatory function is essential for the maintenance of normal muscle tone and function.
Pathways
DMPK participates actively in RhoA and MAPK signaling pathways. DMPK impacts the RhoA pathway by regulating cytoskeletal organization and cell morphology interacting with proteins like Rho kinase to modulate muscle contraction. In the MAPK pathway DMPK plays a role in stress response signaling impacting proteins such as ERK that control gene expression in response to stressors.
Specifications
Form
Liquid
Additional notes
Affinity purified.
General info
Function
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
Post-translational modifications
Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK.. Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity.
Subcellular localisation
Nucleus outer membrane
Target data
Complementary Products
Product promise
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