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AB171692

Recombinant Human EBP2 protein (denatured) (His tag N-Terminus)

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Recombinant Human EBP2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 306 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

EBP2, EBNA1BP2, Probable rRNA-processing protein EBP2, EBNA1-binding protein 2, Nucleolar protein p40

1 Images
SDS-PAGE - Recombinant Human EBP2 protein (denatured) (His tag N-Terminus) (AB171692)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human EBP2 protein (denatured) (His tag N-Terminus) (AB171692)

15% SDS-PAGE analysis of ab171692 (3µg)

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q99848

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as EBNA1 binding protein 2.
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQKPLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTAHGRGLKRPGKKGSNKRPGKRTREKMKNRTH","proteinLength":"Full Length","predictedMolecularWeight":"37.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":306,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99848","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EBP2 also known as Erb plasmid is a nuclear protein involved in ribosomal biosynthesis with a molecular mass of approximately 37 kDa. EBP2 is expressed in various tissues but shows strong expression in actively dividing cells. It participates in the assembly of ribosomal proteins with rRNA a critical element for cellular protein synthesis. Its interactions with the nucleolar structure highlight its core role in ribosome production.
Biological function summary

EBP2 functions in maintaining the integrity of ribosomal biogenesis and cellular proliferation. It is an integral part of the pre-ribosomal complex where it ensures the efficient processing and assembly of rRNA. This relationship is significant for the production of functional ribosomes which in turn support the translation of genetic information into proteins. EBP2's activity impacts cell growth and replication showcasing its vital importance in fundamental biological processes.

Pathways

The EBP2 protein intersects significantly with both ribosomal biogenesis and cell cycle regulation pathways. It closely interacts with rRNA processing pathways maintaining the seamless production of ribosomal subunits necessary for cellular translation machinery. Additionally proteins such as Nop56 and Nop58 relate to EBP2 through these pathways assisting in the assembly and stability of the ribosomal complex. EBP2 in combination with these proteins ensures the proper progression of cells through the cell cycle by managing ribosome synthesis efficiently.

Mutations or dysregulation of EBP2 could potentially relate to cancer and ribosomopathies due to its central role in ribosome production and cell growth regulation. Aberrant expression or function of EBP2 can lead to uncontrolled cell proliferation as seen in certain types of cancer. Its connection to the protein p53 also influences cell cycle control and apoptosis contributing to tumorigenesis when disrupted. Understanding EBP2's function and interactions therefore offers insights into its contribution to disease mechanisms.
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Specifications

Form

Liquid

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General info

Function

Required for the processing of the 27S pre-rRNA.

Sequence similarities

Belongs to the EBP2 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Required for the processing of the 27S pre-rRNA.
See full target information EBNA1BP2
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