Recombinant Human ECRG-2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Epithelial cell-related gene 2 commonly known as ECRG-2 is a protein involved in several cellular processes. The protein has a molecular mass of about 8 kDa. Researchers have found it expressed mainly in the epithelium especially in esophageal tissues but it also appears in several other tissue types. ECRG-2 plays a role in cell differentiation proliferation and apoptosis meaning it has an important function in maintaining healthy cell behavior and tissue development.

Biological function summary

ECRG-2 influences gene expression and impacts cellular responses to stress and injury. It functions as a tumor suppressor and has shown activity inhibiting proliferation of cancer cells. ECRG-2 is not part of any known complex but interacts with various other proteins supporting its suppressor functions. This interaction helps it to regulate cell cycle and protect cells from malignant transformations.

Pathways

ECRG-2 influences several molecular pathways including the p53 pathway. p53 is a critical pathway in cell cycle regulation and apoptosis. ECRG-2 interacts with proteins involved in this pathway reinforcing the prevention of tumor development. Additionally it connects indirectly to pathways involving NF-κB which is important for immune response and inflammation and shares functions with ECRG-2 in regulating cellular growth and apoptosis.

ECRG-2 has been linked to esophageal cancer and gastric cancer. Research suggests reduced expression of ECRG-2 correlates with tumor growth and metastasis. In these cancers it frequently interacts with proteins like p53 and alterations in these interactions can further disease progression. Understanding ECRG-2's role in these conditions assists in developing potential therapeutic strategies that target the molecular pathways associated with these cancers.