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AB219489

Recombinant Human EDA2R/XEDAR protein (His tag)

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Recombinant Human EDA2R/XEDAR protein (His tag) is a Human Fragment protein, in the 1 to 139 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, EDA2R, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor

1 Images
SDS-PAGE - Recombinant Human EDA2R/XEDAR protein (His tag) (AB219489)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human EDA2R/XEDAR protein (His tag) (AB219489)

15% SDS-PAGE - Recombinant Human EDA2R/XEDAR protein (ab219489) at 3 μg.

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9HAV5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>40-57 kDa SDS-PAGE under reducing conditions.</p>" } } }
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Product details

This product was previously labelled as EDA2R
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Sequence info

[{"sequence":"ADPMDCQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQSCITCAVINRVQKVNCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVEADAPTVPPQEATLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"42.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":139,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q9HAV5","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EDA2R also known as XEDAR (X-linked Ectodermal Dysplasia Receptor) is a member of the tumor necrosis factor receptor superfamily. This protein has a mass of approximately 42 kDa. EDA2R is expressed widely in various tissues including the skin hair follicles and glands. Its mechanical role involves binding to specific members of the ectodysplasin family mediating downstream signaling.
Biological function summary

The EDA2R protein engages in ectodermal development processes. It is involved in the formation of skin hair and sweat glands. EDA2R functions by activating signaling pathways that regulate cell development and differentiation. Though primarily a solo actor it interacts with other molecules to carry out its biological actions effectively.

Pathways

EDA2R is actively involved in the NF-kappa B signaling pathway and may intersect with the Wnt signaling pathway. These pathways influence various cellular responses like inflammation and cell growth. EDA2R shares functional pathways with proteins such as EDAR and EDARADD which facilitate the signals through similar or connected mechanisms in the organization of ectodermal structures.

EDA2R has been specifically associated with ectodermal dysplasia a group of disorders affecting skin hair and glands. Mutations or malfunctions in EDA2R can lead to abnormal developments in these tissues. EDA2R also shows relevance in certain cancers where its expression level can impact tumor growth and survival. In both contexts EDAR is a connected protein that often partners with EDA2R to influence disease progression.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

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Product protocols

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Target data

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
See full target information EDA2R
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Primary Antibodies

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