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AB187467

Recombinant Human EDAR protein (denatured) (His tag N-Terminus)

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Recombinant Human EDAR protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 27 to 448 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

DL, EDAR, Tumor necrosis factor receptor superfamily member EDAR, Anhidrotic ectodysplasin receptor 1, Downless homolog, EDA-A1 receptor, Ectodermal dysplasia receptor, Ectodysplasin-A receptor

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SDS-PAGE - Recombinant Human EDAR protein (denatured) (AB187467)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human EDAR protein (denatured) (AB187467)

15% SDS-PAGE analysis of ab187467 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UNE0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS","proteinLength":"Full Length","predictedMolecularWeight":"48.26 kDa","actualMolecularWeight":null,"aminoAcidEnd":448,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UNE0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ectodysplasin A receptor also known as EDAR is a transmembrane protein involved in various developmental processes. It has a molecular mass of approximately 63 kDa. You can find EDAR expression in tissues such as the skin hair follicles and teeth. As a member of the tumor necrosis factor receptor (TNFR) family EDAR plays an important mechanical role by binding ectodysplasin A ligand (EDA) which initiates downstream signals important for developmental pathways.
Biological function summary

The interaction between EDAR and its ligand EDA influences morphogenesis of ectodermal-derived structures. This receptor-ligand binding is integral to the EDAR/NF-kappaB signaling complex. It affects processes such as the formation of hair follicles sweat glands and teeth. The receptor facilitates cell communication necessary for the proper development of these structures ensuring the correct activation of related signaling pathways.

Pathways

EDAR functions within the NF-kappaB and Wnt signaling pathways. These pathways regulate cellular differentiation and proliferation. The receptor collaborates with adapter proteins such as EDARADD to effectively transmit signals downstream. Furthermore it shares significant relationships with other TNF receptor family members highlighting the importance of signaling specificity and coordination within these biological pathways.

Mutations in the EDAR gene associate with ectodermal dysplasia a genetic disorder affecting hair teeth and sweat glands. Additionally EDAR influences the development of hypohidrotic ectodermal dysplasia (HED). The receptor's link with EDA and other TNFR family members highlights the complex genetic interactions contributing to these conditions. Understanding these relationships provides insights into targeted therapeutic strategies addressing developmental abnormalities.
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Specifications

Form

Liquid

Additional notes

ab187467 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.

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General info

Function

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.

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Product protocols

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Target data

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
See full target information EDAR
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