Recombinant Human EDIL3/DEL1 protein (His tag) is a Human Full Length protein, in the 16 to 470 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, WB, MS.
Images
Key facts
- Purity
- >80%
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, WB, MS
- Biologically active
- No
Amino acid sequence
G V P Q F G K G D I C D P N P C E N G G I C L P G L A D G S F S C E C P D G F T D P N C S S V V E V G P C T P N P C H N G G T C E I S E A Y R G D T F I G Y V C K C P R G F N G I H C Q H N I N E C E V E P C K N G G I C T D L V A N Y S C E C P G E F M G R N C Q Y K C S G P L G I E G G I I S N Q Q I T A S S T H R A L F G L Q K W Y P Y Y A R L N K K G L I N A W T A A E N D R W P W I Q I N L Q R K M R V T G V I T Q G A K R I G S P E Y I K S Y K I A Y S N D G K T W A M Y K V K G T N E D M V F R G N I D N N T P Y A N S F T P P I K A Q Y V R L Y P Q V C R R H C T L R M E L L G C E L S G C S E P L G M K S G H I Q D Y Q I T A S S I F R T L N M D M F T W E P R K A R L D K Q G K V N A W T S G H N D Q S Q W L Q V D L L V P T K V T G I I T Q G A K D F G H V Q F V G S Y K L A Y S N D G E H W T V Y Q D E K Q R K D K V F Q G N F D N D T H R K N V I D P P I Y A R H I R I L P W S W Y G R I T L R S E L L G C T E E E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Alternative names
DEL1, EDIL3, EGF-like repeat and discoidin I-like domain-containing protein 3, Developmentally-regulated endothelial cell locus 1 protein, Integrin-binding protein DEL1
Recommended products
Recombinant Human EDIL3/DEL1 protein (His tag) is a Human Full Length protein, in the 16 to 470 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, WB, MS.
Key facts
- Purity
- >80%
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, WB, MS
- Biologically active
- No
- Accession
- O43854-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 5% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.29% Sodium chloride, 0.1% Triton X-100
Sequence info
Amino acid sequence
- G V P Q F G K G D I C D P N P C E N G G I C L P G L A D G S F S C E C P D G F T D P N C S S V V E V G P C T P N P C H N G G T C E I S E A Y R G D T F I G Y V C K C P R G F N G I H C Q H N I N E C E V E P C K N G G I C T D L V A N Y S C E C P G E F M G R N C Q Y K C S G P L G I E G G I I S N Q Q I T A S S T H R A L F G L Q K W Y P Y Y A R L N K K G L I N A W T A A E N D R W P W I Q I N L Q R K M R V T G V I T Q G A K R I G S P E Y I K S Y K I A Y S N D G K T W A M Y K V K G T N E D M V F R G N I D N N T P Y A N S F T P P I K A Q Y V R L Y P Q V C R R H C T L R M E L L G C E L S G C S E P L G M K S G H I Q D Y Q I T A S S I F R T L N M D M F T W E P R K A R L D K Q G K V N A W T S G H N D Q S Q W L Q V D L L V P T K V T G I I T Q G A K D F G H V Q F V G S Y K L A Y S N D G E H W T V Y Q D E K Q R K D K V F Q G N F D N D T H R K N V I D P P I Y A R H I R I L P W S W Y G R I T L R S E L L G C T E E E
- Accession
- O43854
- Protein length
- Full Length
- Predicted molecular weight
- 52 kDa
- Amino acids
- 16 to 470
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Liquid
- Additional notes
Immobilized-metal affinity chromatography (IMAC)
General info
- Function
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as EDIL3.
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein EDIL3 also known as DEL1 or del-1 protein is a secreted extracellular matrix protein with a mass of approximately 52 kDa. It is expressed highly in endothelial cells and has a significant presence during embryonic development particularly within the arteries. As a versatile protein EDIL3 plays a role in promoting cell adhesion through interaction with integrins. This interaction makes it important for cellular communication and structural support in various tissues.
- Biological function summary
EDIL3 influences vascular development and angiogenesis. It is not generally part of a large protein complex but works independently to support endothelial cell survival and proliferation. It binds preferentially to integrins like alphavbeta3 and alphavbeta5. This binding initiates intracellular signaling cascades that activate pathways responsible for cell growth and migration. EDIL3 therefore contributes to stabilizing newly formed blood vessels which is essential during developmental processes.
- Pathways
EDIL3 plays a role in the regulation of several signaling networks including the MAPK and PI3K/AKT pathways. In these pathways it assists angiogenesis and endothelial cell function by activating signaling that promotes cell division and survival. EDIL3-related pathway interactions involve proteins such as VEGF an important factor in angiogenesis which also partners with integrins to enhance vascular development and repair processes.
- Associated diseases and disorders
EDIL3 has implications in cancer and inflammatory diseases. In cancer EDIL3 aids the formation of new blood vessels that supply nutrients to tumors promoting their growth and metastasis. It partners with the VEGF protein to enhance angiogenic processes in tumor environments. Inflammatory diseases such as rheumatoid arthritis show elevated levels of EDIL3 where it encourages pro-inflammatory responses through endothelial cell interactions. Here EDIL3 might interact with proteins involved in inflammatory pathways exacerbating disease progression.
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2 product images
Western blot - Recombinant Human EDIL3/DEL1 protein (His tag) (ab204774)
Western blot analysis of ab204774.
All lanes: Western blot - Recombinant Human EDIL3/DEL1 protein (His tag) (ab204774)
SDS-PAGE - Recombinant Human EDIL3/DEL1 protein (His tag) (ab204774)
10% SDS-PAGE analysis of ab204774 stained with Coomassie Blue.
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