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AB132296

Recombinant Human EFHD2/SWS1 protein (GST tag N-Terminus)

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Recombinant Human EFHD2/SWS1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

SWS1, EFHD2, EF-hand domain-containing protein D2, Swiprosin-1

1 Images
SDS-PAGE - Recombinant Human EFHD2/SWS1 protein (GST tag N-Terminus) (AB132296)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human EFHD2/SWS1 protein (GST tag N-Terminus) (AB132296)

12.5% SDS-PAGE stained with Coomassie Blue showing ab132296.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Q96C19

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

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Complementary Products

Primary Antibodies

AB106667

Anti-EFHD2/SWS1 antibody

Western blot - Anti-EFHD2/SWS1 antibody (AB106667)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB156742

Recombinant Human OSCAR/Osteoclast-associated receptor protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human OSCAR/Osteoclast-associated receptor protein (denatured) (His tag N-Terminus) (AB156742)

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Proteins & Peptides

AB156725

Recombinant Human FLJ11506 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human FLJ11506 protein (His tag N-Terminus) (AB156725)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MATDELATKLSRRLQMEGEGGGETPEQPGLNGAAAAAAGAPDEAAEALGSADCELSAKLLRRADLNQGIGEPQSPSRRVFNPYTEFKEFSRKQIKDMEKMFKQYDAGRDGFIDLMELKLMMEKLGAPQTHLGLKNMIKEVDEDFDSKLSFREFLLIFRKAAAGELQEDSGLCVLARLSEIDVSSEGVKGAKSFFEAKVQAINVSSRFEEEIKAEQEERKKQAEEMKQRKAAFKELQSTFK","proteinLength":"Full Length","predictedMolecularWeight":"53.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":240,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96C19","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EFHD2 also known as SWS1 is a calcium-binding protein with a mass of approximately 25 kilodaltons. It has an EF-hand motif that facilitates interaction with calcium ions playing a role in actin cytoskeleton dynamics. EFHD2 expresses in several tissues particularly in the brain immune cells and certain cancer cell lines. Its presence in these tissues suggests diverse roles ranging from neurotransmission to immune response modulation.
Biological function summary

This protein participates in cell communication and signaling. It serves an important function in various cellular processes and is a component of the neuronal signalosome complex. EFHD2 interacts with actin filaments and influences cell morphology and migration especially in neurons. It also modulates neuronal plasticity affecting learning and memory processes by impacting synaptic activity and stability.

Pathways

The protein EFHD2 is involved in the calcium signaling pathway which is important for cellular responses and adaptations to external signals. It connects with proteins like CAMKII and calcineurin in this pathway modulating their activity. EFHD2 also participates in the immune signaling cascade partnering with proteins such as SLP-76 and VAV to regulate immune cell activation and function.

EFHD2 has links to neurodegenerative diseases like Alzheimer's and immune-related conditions such as rheumatoid arthritis. In Alzheimer's disease modifications in EFHD2 influence tau protein dynamics contributing to neurofibrillary tangle formation. The protein's dysregulation in rheumatoid arthritis affects NF-kB signaling altering the inflammation response. Overall EFHD2's activity and interactions with other proteins are significant in understanding these disorders' pathophysiology.
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Specifications

Form

Liquid

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General info

Function

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.

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Product protocols

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Target data

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
See full target information EFHD2
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Product promise

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