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AB164305

Recombinant Human EGFL8 protein (GST tag N-Terminus)

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Recombinant Human EGFL8 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 293 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C6orf8, NG3, UNQ8752/PRO29920, EGFL8, Epidermal growth factor-like protein 8, EGF-like protein 8, Vascular endothelial statin-2, VE-statin-2

1 Images
SDS-PAGE - Recombinant Human EGFL8 protein (GST tag N-Terminus) (AB164305)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human EGFL8 protein (GST tag N-Terminus) (AB164305)

ab164305 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q99944

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSRAELCTLLGGFSFLLLLIPGEGAKGGSLRESQGVCSKQTLVVPLHYNESYSQPVYKPYLTLCAGRRICSTYRTMYRVMWREVRREVQQTHAVCCQGWKKRHPGALTCEAICAKPCLNGGVCVRPDQCECAPGWGGKHCHVDVDECRTSITLCSHHCFNTAGSFTCGCPHDLVLGVDGRTCMEGSPEPPTSASILSVAVREAEKDERALKQEIHELRGRLERLEQWAGQAGAWVRAVLPVPPEELQPEQVAELWGRGDRIESLSDQVLLLEERLGACSCEDNSLGLGVNHR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":293,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99944","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EGFL8 also known as epidermal growth factor-like protein 8 is a protein encoded by the EGFL8 gene. This protein weighs approximately 57 kDa and is part of the epidermal growth factor (EGF) family characterized by the presence of EGF-like domains. EGFL8 is expressed in various tissues particularly in the central nervous system and developing organs. These domains facilitate the protein's role in cellular signaling as they can bind to receptors and influence cell growth and differentiation.
Biological function summary

EGFL8 interacts with other proteins to modulate diverse processes including neurodevelopment and organogenesis. It plays an important role in cell adhesion proliferation and migration by engaging with cell surface receptors. The protein may also exist in a complex with other extracellular matrix proteins further influencing its function in tissue architecture. Its regulatory function suggests a potential involvement in maintaining cellular environment and responding to growth signals.

Pathways

EGFL8 is significantly involved in signaling cascades that are important for developmental processes. Notably it participates in the MAPK/ERK pathway where it influences cell cycle dynamics and differentiation. This pathway also involves other proteins such as Ras and MEK which convey signals from growth factor receptors to the nucleus. EGFL8 may also have interactions with the Notch signaling pathway which is essential for various developmental processes and cell fate determination.

EGFL8 has implications in the progression of certain neurodevelopmental disorders and cancers. Its altered expression or mutations can affect normal development potentially contributing to conditions such as autism spectrum disorder and brain tumors. The protein may interact with other dysregulated proteins in these diseases including Notch signaling components and EGF receptor pathways further complicating disease mechanisms and clinical outcomes.
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Specifications

Form

Liquid

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General info

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Product protocols

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Target data

See full target information EGFL8
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Product promise

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