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AB264454

Recombinant Human EHF protein (His tag)

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Recombinant Human EHF protein (His tag) is a Human Full Length protein, in the 1 to 300 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

ESE3, ESE3B, ESEJ, EHF, ETS homologous factor, hEHF, ETS domain-containing transcription factor, Epithelium-specific Ets transcription factor 3, ESE-3

1 Images
SDS-PAGE - Recombinant Human EHF protein (His tag) (AB264454)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human EHF protein (His tag) (AB264454)

SDS-PAGE analysis of ab264454 (3 μg) under reducing conditions. Coomassie Blue staining. 15% SDS-PAGE gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NZC4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN","proteinLength":"Full Length","predictedMolecularWeight":"37.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":300,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NZC4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

EHF also known as Ets homologous factor is a transcription factor within the ETS family featuring a mass of approximately 37 kDa. EHF regulates gene expression by binding to DNA sequences known as ETS motifs and influences the transcriptional processes. It exhibits significant expression in epithelial tissues including the lungs and esophagus indicating its importance in cellular activities within these tissues.
Biological function summary

This protein contributes to the regulation of epithelial cell differentiation and proliferation. EHF is not generally known to be a part of specific protein complexes but works closely with other ETS family transcription factors to exert its effects on target genes. Its influence extends to controlling factors that maintain epithelial integrity and function making it important for normal tissue development and homeostasis.

Pathways

EHF impacts gene expression involved in the growth signaling and differentiation. It participates chiefly in pathways such as the MAPK/ERK pathway influencing cell cycle regulation and response to growth stimuli. EHF interacts with various MAPK proteins coordinating cellular responses that dictate epithelial cell fate decisions.

EHF correlates with conditions like cancer and inflammatory disorders. Aberrant EHF expression links to certain malignancies including lung and esophageal cancers where it may act as a tumor suppressor or promoter depending on the context. In inflammatory disorders dysregulation of EHF expression affects pathways alongside proteins such as NF-kB contributing to chronic inflammation and disease progression.
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Specifications

Form

Liquid

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General info

Function

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Sequence similarities

Belongs to the ETS family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.
See full target information EHF
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