Recombinant Human EIF1B protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The EIF1B protein also known as eukaryotic translation initiation factor 1B plays an important mechanical role in the initiation phase of translating mRNA into proteins. It has a mass of around 19 kDa and is involved in the assembly of the pre-initiation complex that allows the scanning of the mRNA. EIF1B is typically expressed in various tissues including brain and liver contributing to its essential function in protein synthesis.

Biological function summary

EIF1B facilitates the accurate selection of the start codon during protein synthesis. It forms part of a complex with other initiation factors such as EIF1 to ensure mRNA translation begins correctly. This ensures proteins are synthesized properly which is essential for maintaining cellular function and growth. By interacting with the ribosomal subunit EIF1B contributes to the stabilization and activity of the translation process.

Pathways

EIF1B plays an important role in the mTOR signaling pathway and the general mechanism of translation initiation. In these pathways it interacts with various proteins like EIF3 that regulate protein synthesis in response to different cellular conditions. Its involvement in these signaling pathways ensures cells can adapt to nutritional and environmental changes by controlling protein production levels.

Disruptions in EIF1B function link to conditions such as cancer and neurological disorders. Abnormal EIF1B expression affects the regulation of protein synthesis one of the factors contributing to tumorigenesis and improper neuronal function. It often associates with misregulated proteins such as mTOR and its pathway partners which are important in these diseases. Understanding EIF1B’s role and its connections to these disorders can provide insights into potential therapeutic targets.